Document Detail


Modifications of experimental bronchopulmonary hyperresponsiveness.
MedLine Citation:
PMID:  9351587     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Bronchopulmonary hyperresponsiveness (BHR) is a hallmark of asthma and other inflammatory diseases of the airways. Animal models of BHR are available in which systemic or local immunizations, followed by acute allergenic provocations into the airways, augment responses to intravenous or intratracheal nonspecific bronchoconstrictor agents. Guinea-pig models are easy to manipulate but have serious handicaps: lack of proper genetics, lack of biomolecular tools, and frequent excess of eosinophils in the bronchoalveolar lavage fluid (BALF). Murine models have proper genetics and molecular tools, and they have the further advantage of being widely used for the study of other pathologies. In many of these studies, interleukin (IL)-5 appears as a major cytokine, produced by Th2 lymphocytes. Interleukin-5 promotes eosinophil differentiation and maturation, recruitment to the airways, and possibly activation. The presence of eosinophils in the airways and in the BALF may be necessary but is not sufficient to support BHR, since intense eosinophilia may be present in its absence. Bronchopulmonary hyperresponsiveness is also induced by the administration of lipopolysaccharide (LPS); in that case, eosinophils are not involved, and the role of neutrophils and of tumor necrosis factor-alpha, even though likely, has not been proven. Comparison of BHR induced by allergen (Th2- and largely eosinophil-dependent) and by LPS (probably macrophage-dependent) should allow for a better understanding of the mechanisms of BHR and for the development of important remedies.
Authors:
B B Vargaftig
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  American journal of respiratory and critical care medicine     Volume:  156     ISSN:  1073-449X     ISO Abbreviation:  Am. J. Respir. Crit. Care Med.     Publication Date:  1997 Oct 
Date Detail:
Created Date:  1997-11-06     Completed Date:  1997-11-06     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9421642     Medline TA:  Am J Respir Crit Care Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  S97-102     Citation Subset:  AIM; IM    
Affiliation:
Unité de Pharmacologie Cellulaire, Institut Pasteur, Paris, France.
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MeSH Terms
Descriptor/Qualifier:
Animals
Bone Marrow / pathology
Bronchial Hyperreactivity / genetics,  immunology*
Disease Models, Animal*
Eosinophilia / immunology
Eosinophils / immunology*
Guinea Pigs
Humans
Immunity, Cellular
Lipopolysaccharides / immunology
Lymphocytes / immunology*
Mice
Mice, Inbred Strains
Species Specificity
Chemical
Reg. No./Substance:
0/Lipopolysaccharides

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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