| Modifications of cardiac function in cirrhotic patients treated with transjugular intrahepatic portosystemic shunt (TIPS). | |
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MedLine Citation:
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PMID: 11808939 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: The implantation of a transjugular intrahepatic portosystemic shunt (TIPS) has been shown to exacerbate the hyperdynamic circulation and might induce a significant cardiac overload. We investigated cardiac function before and 1, 3, 6, and 12 months after the TIPS procedure in cirrhotic patients. METHODS: Eleven patients with nonalcoholic cirrhosis were evaluated. Cardiovascular parameters were assessed by two-dimensional Doppler echocardiography. RESULTS: After TIPS, the left ventricular diastolic diameter increased from 26.5 +/- 1.8 mm (basal) to 30.0 +/- 2.8 mm (6 months) (p < 0.05), whereas the ejection fraction showed a slight increase (basal, 64.5 +/- 3.3; 6 months, 68.1 +/- 3.2). The left ventricular pre-ejection period and the isovolumetric relaxation time decreased transiently at 1 month (p < 0.05). An increased velocity in all of the components of pulmonary venous flow (systolic, diastolic, and atrial) documented the accelerated fluxes induced by the procedure. The estimated pulmonary systolic arterial pressure also increased at 1 month (29.5 +/- 1.4 vs 44.1 +/- 1.4 mm Hg, p < 0.05). All of these modifications reverted after 6 months. CONCLUSIONS: Our study demonstrates that nonalcoholic cirrhotic patients, without cardiovascular pathologies, show transient modifications in cardiac dimension and function for 3-6 months after TIPS caused by the increased volume load shunted to the heart. |
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Authors:
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Manuela Merli; Valentina Valeriano; Stefania Funaro; Adolfo Francesco Attili; Andrea Masini; Cesare Efrati; Castro Stefano De; Oliviero Riggio |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The American journal of gastroenterology Volume: 97 ISSN: 0002-9270 ISO Abbreviation: Am. J. Gastroenterol. Publication Date: 2002 Jan |
Date Detail:
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Created Date: 2002-01-25 Completed Date: 2002-02-07 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0421030 Medline TA: Am J Gastroenterol Country: United States |
Other Details:
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Languages: eng Pagination: 142-8 Citation Subset: IM |
Affiliation:
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Department of Clinical Medicine, University of Rome La Sapienza, Italy. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Cardiovascular Diseases / complications, ultrasonography* Echocardiography, Doppler Female Follow-Up Studies Heart Function Tests Hemodynamics / physiology Humans Liver Cirrhosis / complications, diagnosis, surgery* Male Middle Aged Portasystemic Shunt, Transjugular Intrahepatic / methods* Postoperative Period Preoperative Care Probability Prospective Studies Sensitivity and Specificity Time Factors Treatment Outcome |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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