Document Detail

Modification of a volume-overload heart failure model to track myocardial remodeling and device-related reverse remodeling.
MedLine Citation:
PMID:  22347659     Owner:  NLM     Status:  In-Data-Review    
Purpose. To provide an ovine model of ventricular remodeling and reverse remodeling by creating congestive heart failure (CHF) and then treating it by implanting a left ventricular assist device (LVAD). Methods. We induced volume-overload heart failure in 2 sheep; 20 weeks later, we implanted an LVAD and assessed recovery 11 weeks thereafter. We examined changes in histologic and hemodynamic data and levels of cellular markers of CHF. Results. After CHF induction, we found increases in LV end-diastolic pressure, LV systolic and diastolic dimensions, wall thickness, left atrial diameter, and atrial natriuretic protein (ANP) and endothelin-1 (ET-1) levels; β-adrenergic receptor (BAR) and dystrophin expression decreased markedly. Biopsies confirmed LV remodeling. After LVAD support, LV systolic and diastolic dimensions, wall thickness, and mass, and ANP and ET-1 levels decreased. Histopathologic and hemodynamic markers improved, and BAR and dystrophin expression normalized. Conclusions. We describe a successful sheep model for ventricular and reverse remodeling.
Egemen Tuzun; Roger Bick; Cihan Kadipasaoglu; Jeffrey L Conger; Brian J Poindexter; Igor D Gregoric; O H Frazier; Jeffrey A Towbin; Branislav Radovancevic
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Publication Detail:
Type:  Journal Article     Date:  2011-07-06
Journal Detail:
Title:  ISRN cardiology     Volume:  2011     ISSN:  2090-5599     ISO Abbreviation:  ISRN Cardiol     Publication Date:  2011  
Date Detail:
Created Date:  2012-02-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101566293     Medline TA:  ISRN Cardiol     Country:  Egypt    
Other Details:
Languages:  eng     Pagination:  831062     Citation Subset:  -    
Cardiovascular Surgical Research Laboratories, Texas Heart Institute, Houston, TX 77225, USA.
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