| Modification of small bowel mechanosensitivity by intestinal fat. | |
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MedLine Citation:
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PMID: 11302970 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Lipids may exacerbate symptoms induced by gut stimuli. AIM: To determine the mechanism whereby fat exerts this effect. SUBJECTS: Twenty four healthy subjects were studied during fasting. METHODS: We measured perception (0-6 scale) in response to jejunal balloon distension and transmucosal electrical nerve stimulation; phasic stimuli (one minute) were randomly applied at five minute intervals during intestinal infusion (2 ml/min) of saline and then Intralipid 2 kcal/min (high fat; n=8 subjects), Intralipid 0.5 kcal/min (low fat; n=8), or saline (n=8). RESULTS: Intestinal lipids increased the perception of jejunal distension regardless of concentration (by 53% with high fat, 49% with low fat, and 17% with saline; p<0.05 for both fat loads). This effect could not be attributed to changes in intestinal compliance as intraballoon pressures remained unchanged during lipid infusion (2% change; NS). Sensitisation induced by lipids seemed to be specifically related to intestinal mechanoreceptors because electrical stimulation, which non-specifically activates gut afferents, was perceived equally during saline and lipid administration (10%, 11%, and 15% change during high fat, low fat, and saline, respectively; NS). CONCLUSION: Physiological amounts of lipids heighten intestinal sensitivity by modulating intestinal mechanoreceptor response. |
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Authors:
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A M Accarino; F Azpiroz; J R Malagelada |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Gut Volume: 48 ISSN: 0017-5749 ISO Abbreviation: Gut Publication Date: 2001 May |
Date Detail:
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Created Date: 2001-04-16 Completed Date: 2001-05-17 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 2985108R Medline TA: Gut Country: England |
Other Details:
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Languages: eng Pagination: 690-5 Citation Subset: AIM; IM |
Affiliation:
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Digestive System Research Unit, Hospital General Vall d'Hebron, Autonomous University of Barcelona, Barcelona, Spain. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Balloon Dilatation Dietary Fats / pharmacology* Fasting / physiology Female Humans Jejunum / drug effects, physiology* Male Mechanoreceptors / drug effects, physiology* Pain Measurement Perception / physiology Sodium Chloride / pharmacology Statistics, Nonparametric Transcutaneous Electric Nerve Stimulation |
| Chemical | |
Reg. No./Substance:
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0/Dietary Fats; 7647-14-5/Sodium Chloride |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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