Document Detail

Modification of skin composition by conjugated linoleic acid alone or with combination of other fatty acids in mice.
MedLine Citation:
PMID:  16115363     Owner:  NLM     Status:  MEDLINE    
The effects of conjugated linoleic acid (CLA), gamma-linolenic acid (GLA), linoleic acid (LA), and their combinations, on skin composition in mice were investigated. Mice (8 weeks old) were orally administered with either LA, GLA, CLA, LA + GLA, LA + CLA, or CLA + GLA for 4 weeks. Then, the skin was analysed for triacylglycerol content, fatty acid composition and collagen content. Additionally, thicknesses of the dermis layer and subcutaneous tissue layer, and the size and number of adipocytes were measured histologically. The skin fatty acid composition was modified depending upon the fatty acid composition of supplemented oils. In each oil-alone group, skin triacylglycerol content was the highest in LA, followed by GLA and CLA treatments. Combinations with CLA had a similar triacylglycerol content compared with the CLA-alone group. No significant changes in collagen content were observed among any treatments. The effects on subcutaneous thickness were similar to the results obtained in the triacylglycerol contents, where groups supplemented with CLA alone or other fatty acids had significantly thinner subcutaneous tissue compared with the LA-alone group. However, no significant difference was detected in the thickness of the dermis layers. The number of adipocytes was highest in the LA + GLA group and tended to be reduced by CLA with or without the other fatty acids. These results suggest that CLA alone or in combination with other fatty acids strongly modifies skin composition in mice.
Daichi Oikawa; Tomonori Nakanishi; Yoshi-nori Nakamura; Takaya Yamamoto; Atsuko Yamaguchi; Nobuya Shiba; Hisao Iwamoto; Tetsuya Tachibana; Mitsuhiro Furuse
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The British journal of nutrition     Volume:  94     ISSN:  0007-1145     ISO Abbreviation:  Br. J. Nutr.     Publication Date:  2005 Aug 
Date Detail:
Created Date:  2005-08-23     Completed Date:  2005-10-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372547     Medline TA:  Br J Nutr     Country:  England    
Other Details:
Languages:  eng     Pagination:  275-81     Citation Subset:  IM    
Laboratory of Advanced Animal and Marine Bioresources, Graduate School of Bioresources and Bioenvironmental Sciences, Kyushu University, Fukuoka 812-8581, Japan.
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MeSH Terms
Administration, Oral
Dermis / anatomy & histology,  drug effects,  ultrastructure
Linoleic Acid / administration & dosage*
Linoleic Acids, Conjugated / administration & dosage*
Microscopy, Electron, Scanning / methods
Skin / chemistry,  drug effects*,  ultrastructure
Subcutaneous Tissue / anatomy & histology,  drug effects,  ultrastructure
Triglycerides / analysis
gamma-Linolenic Acid / administration & dosage*
Reg. No./Substance:
0/Linoleic Acids, Conjugated; 0/Triglycerides; 2197-37-7/Linoleic Acid; 506-26-3/gamma-Linolenic Acid

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