| Modification of skin composition by conjugated linoleic acid alone or with combination of other fatty acids in mice. | |
| | |
MedLine Citation:
|
PMID: 16115363 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The effects of conjugated linoleic acid (CLA), gamma-linolenic acid (GLA), linoleic acid (LA), and their combinations, on skin composition in mice were investigated. Mice (8 weeks old) were orally administered with either LA, GLA, CLA, LA + GLA, LA + CLA, or CLA + GLA for 4 weeks. Then, the skin was analysed for triacylglycerol content, fatty acid composition and collagen content. Additionally, thicknesses of the dermis layer and subcutaneous tissue layer, and the size and number of adipocytes were measured histologically. The skin fatty acid composition was modified depending upon the fatty acid composition of supplemented oils. In each oil-alone group, skin triacylglycerol content was the highest in LA, followed by GLA and CLA treatments. Combinations with CLA had a similar triacylglycerol content compared with the CLA-alone group. No significant changes in collagen content were observed among any treatments. The effects on subcutaneous thickness were similar to the results obtained in the triacylglycerol contents, where groups supplemented with CLA alone or other fatty acids had significantly thinner subcutaneous tissue compared with the LA-alone group. However, no significant difference was detected in the thickness of the dermis layers. The number of adipocytes was highest in the LA + GLA group and tended to be reduced by CLA with or without the other fatty acids. These results suggest that CLA alone or in combination with other fatty acids strongly modifies skin composition in mice. |
| | |
Authors:
|
Daichi Oikawa; Tomonori Nakanishi; Yoshi-nori Nakamura; Takaya Yamamoto; Atsuko Yamaguchi; Nobuya Shiba; Hisao Iwamoto; Tetsuya Tachibana; Mitsuhiro Furuse |
Related Documents
:
|
21630463 - Proteomics analysis of bifidobacterium longum ncc2705 growing on glucose, fructose, man... 15028873 - Isolation and characterization of a lipoxygenase from pseudomonas 42a2 responsible for ... 9703903 - Role of hydrogen peroxide in antitumor activity induction by sodium 5,6-benzylidene-l-a... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: The British journal of nutrition Volume: 94 ISSN: 0007-1145 ISO Abbreviation: Br. J. Nutr. Publication Date: 2005 Aug |
Date Detail:
|
Created Date: 2005-08-23 Completed Date: 2005-10-11 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0372547 Medline TA: Br J Nutr Country: England |
Other Details:
|
Languages: eng Pagination: 275-81 Citation Subset: IM |
Affiliation:
|
Laboratory of Advanced Animal and Marine Bioresources, Graduate School of Bioresources and Bioenvironmental Sciences, Kyushu University, Fukuoka 812-8581, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Administration, Oral Animals Dermis / anatomy & histology, drug effects, ultrastructure Linoleic Acid / administration & dosage* Linoleic Acids, Conjugated / administration & dosage* Male Mice Microscopy, Electron, Scanning / methods Skin / chemistry, drug effects*, ultrastructure Subcutaneous Tissue / anatomy & histology, drug effects, ultrastructure Triglycerides / analysis gamma-Linolenic Acid / administration & dosage* |
| Chemical | |
Reg. No./Substance:
|
0/Linoleic Acids, Conjugated; 0/Triglycerides; 2197-37-7/Linoleic Acid; 506-26-3/gamma-Linolenic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Prolonged feeding of difructose anhydride III increases strength and mineral concentrations of the f...
Next Document: Obesity induced during sexual maturation is linked to LDL-triacylglycerols in Yucatan miniature swin...