Document Detail

Modification of the sensitivity of CHO cells to mitomycin C by dibutyryl cyclic AMP.
MedLine Citation:
PMID:  6299289     Owner:  NLM     Status:  MEDLINE    
The survival of CHO cells exposed to mitomycin C was decreased three times that of the cells treated with 1 mM dibutyryl cyclic AMP before mitomycin C treatment, as compared to the absence of treatment with this cyclic nucleotide. The sensitization effect began at 3-4 hours after the start of pre-treatment, reached a maximum at around 10 hours and continued to be effective. Post-treatment with the cyclic nucleotide for more than 12 hours increased the survival of CHO cells exposed to mitomycin C.
S Shinohara; Y Otsu; T Yamada; H Kimura; T Aoyama
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  111     ISSN:  0006-291X     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  1983 Feb 
Date Detail:
Created Date:  1983-04-15     Completed Date:  1983-04-15     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  247-52     Citation Subset:  IM    
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MeSH Terms
Bucladesine / pharmacology*
Cell Line
Cell Survival / drug effects
Mitomycins / pharmacology*
Ovary / drug effects*
Reg. No./Substance:
0/Mitomycins; 362-74-3/Bucladesine; 50-07-7/Mitomycin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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