Document Detail

Modification of the responses of endothelin-1 to exhaustive physical exercise under simulated high-altitude conditions with acute hypoxia.
MedLine Citation:
PMID:  7854170     Owner:  NLM     Status:  MEDLINE    
To assess whether acute alveolar hypoxia leads to the release of endothelin-1 (ET) in vivo, ET, cortisol (CORT), and lactate (LA) levels were determined in 15 healthy subjects at rest and during exhaustive incremental cycle ergometry on two separate test days. The subjects were to breathe a gas mixture with reduced O2 content ([H] fraction of inspired O2, 0.14) on one day and normal air on the other (N). Modified responses of LA and CORT to exhaustive incremental cycle ergometry on the H day indicated elevated anaerobic tissue metabolism and increased physical stress. With acute alveolar hypoxia, the response of ET to exhaustive physical labor was found to be augmented.
T Kullmer; E Jungmann; T Haak; K H Usadel
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Metabolism: clinical and experimental     Volume:  44     ISSN:  0026-0495     ISO Abbreviation:  Metab. Clin. Exp.     Publication Date:  1995 Jan 
Date Detail:
Created Date:  1995-03-14     Completed Date:  1995-03-14     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0375267     Medline TA:  Metabolism     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  8-9     Citation Subset:  IM; S    
Department of Internal Medicine, University Hospital Frankfurt am Main, Germany.
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MeSH Terms
Acute Disease
Anoxia / blood*
Endothelins / blood*
Hydrocortisone / blood
Lactates / blood
Lactic Acid
Physical Exertion*
Reg. No./Substance:
0/Endothelins; 0/Lactates; 50-21-5/Lactic Acid; 50-23-7/Hydrocortisone

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