Document Detail

Modification of the rat uterine response to oestrogen and tamoxifen by thromboxane antagonists.
MedLine Citation:
PMID:  1364847     Owner:  NLM     Status:  MEDLINE    
1. The thromboxane receptor antagonists EP092, AH23848 and BM 13.505 were used to investigate the role of thromboxane in the uterotrophic response to oestradiol and tamoxifen. 2. The parameters examined were uterine blood flow (measured by the microsphere technique), uterine wet and dry weights and the concentrations of cytosolic and nuclear oestrogen receptors. 3. Only EP092 potentiated the hyperaemic response to oestrogen but all three thromboxane antagonists inhibited oestradiol-stimulated uterine growth. This inhibition was accompanied by a decrease in nuclear oestrogen receptor concentration. 4. The uterotrophic response to tamoxifen was unaffected by the thromboxane antagonists. 5. The mechanism by which the thromboxane antagonists may be exerting their growth inhibitory effect is discussed, although, whether this effect can be attributed to blockade of thromboxane receptors or to some other mechanism is not clear from this study.
M B Kerr; K Marshall; J Senior
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British journal of pharmacology     Volume:  102     ISSN:  0007-1188     ISO Abbreviation:  Br. J. Pharmacol.     Publication Date:  1991 Mar 
Date Detail:
Created Date:  1995-01-05     Completed Date:  1995-01-05     Revised Date:  2010-09-07    
Medline Journal Info:
Nlm Unique ID:  7502536     Medline TA:  Br J Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  742-6     Citation Subset:  IM    
Postgraduate School of Studies in Pharmacology, University of Bradford, West Yorkshire.
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MeSH Terms
Biphenyl Compounds / pharmacology
Estradiol / pharmacology*
Organ Size / drug effects
Phenylacetates / pharmacology
Prostaglandins, Synthetic / pharmacology
Rats, Sprague-Dawley
Receptors, Estrogen / analysis,  drug effects
Regional Blood Flow / drug effects
Sulfonamides / pharmacology
Tamoxifen / pharmacology*
Thromboxanes / antagonists & inhibitors*
Uterus / blood supply,  drug effects*
Reg. No./Substance:
0/Biphenyl Compounds; 0/Phenylacetates; 0/Prostaglandins, Synthetic; 0/Receptors, Estrogen; 0/Sulfonamides; 0/Thromboxanes; 105218-03-9/daltroban; 10540-29-1/Tamoxifen; 50-28-2/Estradiol; 81443-73-4/AH 23848; 96384-09-7/EP 092

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