Document Detail


Modification of progesterone and testosterone by a food-borne thermophile Geobacillus kaustophilus.
MedLine Citation:
PMID:  19961354     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The present work was carried out to study structural modification of steroids by Geobacillus kaustophilus, a bacterial thermophile present in milk and the environment. Incubation of progesterone and testosterone with G. kaustophilus at 65 degrees C resulted in oxygenated steroid nuclei. The oxygenation of the steroid molecule was stereo specific. Seven metabolites of progesterone horizontal line 6beta/6alpha-hydroxytestosterone, 20-hydroxyprogesterone, 6beta-/6alpha-20-dihydroxyprogesterone, 5alpha-pregnane-3,6,20-trione, and 3beta-hydroxy-5alpha-pregnane-6,20-dione horizontal line were identified. Four compounds horizontal line namely, 66-/6--hydroxytestosterone and 6beta/6alpha-hydroxyandrostenedione horizontal line and androst-4-en-3,17-dione were identified as testosterone metabolites. This shows that G. kaustophilus is capable of modifying steroid nuclei at elevated temperatures. G. kaustophilus is a stable thermophile first isolated from milk. Our results show that endogenous steroids present in milk can be modified by G. kaustophilus, causing detrimental effect on human health.
Authors:
Safa Al-Tamimi; Sameera Al-Awadi; Sosamma Oommen; Mohammad Afzal
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of food sciences and nutrition     Volume:  61     ISSN:  1465-3478     ISO Abbreviation:  Int J Food Sci Nutr     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-01-18     Completed Date:  2010-04-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9432922     Medline TA:  Int J Food Sci Nutr     Country:  England    
Other Details:
Languages:  eng     Pagination:  78-86     Citation Subset:  IM    
Affiliation:
Department of Biological Sciences, Faculty of Science, Kuwait University, Kuwait.
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MeSH Terms
Descriptor/Qualifier:
Animals
Food Microbiology*
Geobacillus / metabolism*
Humans
Milk / microbiology*
Oxidation-Reduction
Oxygen / metabolism
Progesterone / metabolism*
Testosterone / metabolism*
Chemical
Reg. No./Substance:
57-83-0/Progesterone; 58-22-0/Testosterone; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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