| Modification of the polar head group of platelet-activating factor: influence on the biological activity. | |
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MedLine Citation:
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PMID: 3607969 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Racemic analogues of platelet-activating factor and its lyso derivatives have been prepared in which one methyl of the trimethylammonium group has been replaced by ethyl, propyl, allyl, or carboxymethylene. The influence of chemical modification on the biological activity was assessed by measuring platelet aggregation and desensitization. The results point to a crucial role of a positively charged polar head group for the expression of biological activity of platelet-activating factor. There are also some indications of a more non-specific interaction of the polar head group of platelet-activating factor with its platelet binding sites. |
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Authors:
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G Ostermann; H P Kertscher; A Lang; U Till |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Chemistry and physics of lipids Volume: 43 ISSN: 0009-3084 ISO Abbreviation: Chem. Phys. Lipids Publication Date: 1987 May |
Date Detail:
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Created Date: 1987-09-09 Completed Date: 1987-09-09 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0067206 Medline TA: Chem Phys Lipids Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 247-55 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Humans Platelet Activating Factor* / analogs & derivatives, physiology Platelet Aggregation* Structure-Activity Relationship |
| Chemical | |
Reg. No./Substance:
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0/O-deacetyl platelet activating factor; 0/Platelet Activating Factor |
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