Document Detail

Modification of the polar head group of platelet-activating factor: influence on the biological activity.
MedLine Citation:
PMID:  3607969     Owner:  NLM     Status:  MEDLINE    
Racemic analogues of platelet-activating factor and its lyso derivatives have been prepared in which one methyl of the trimethylammonium group has been replaced by ethyl, propyl, allyl, or carboxymethylene. The influence of chemical modification on the biological activity was assessed by measuring platelet aggregation and desensitization. The results point to a crucial role of a positively charged polar head group for the expression of biological activity of platelet-activating factor. There are also some indications of a more non-specific interaction of the polar head group of platelet-activating factor with its platelet binding sites.
G Ostermann; H P Kertscher; A Lang; U Till
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Chemistry and physics of lipids     Volume:  43     ISSN:  0009-3084     ISO Abbreviation:  Chem. Phys. Lipids     Publication Date:  1987 May 
Date Detail:
Created Date:  1987-09-09     Completed Date:  1987-09-09     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0067206     Medline TA:  Chem Phys Lipids     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  247-55     Citation Subset:  IM    
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MeSH Terms
Platelet Activating Factor* / analogs & derivatives,  physiology
Platelet Aggregation*
Structure-Activity Relationship
Reg. No./Substance:
0/O-deacetyl platelet activating factor; 0/Platelet Activating Factor

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