Document Detail


Modification of the polar head group of platelet-activating factor: influence on the biological activity.
MedLine Citation:
PMID:  3607969     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Racemic analogues of platelet-activating factor and its lyso derivatives have been prepared in which one methyl of the trimethylammonium group has been replaced by ethyl, propyl, allyl, or carboxymethylene. The influence of chemical modification on the biological activity was assessed by measuring platelet aggregation and desensitization. The results point to a crucial role of a positively charged polar head group for the expression of biological activity of platelet-activating factor. There are also some indications of a more non-specific interaction of the polar head group of platelet-activating factor with its platelet binding sites.
Authors:
G Ostermann; H P Kertscher; A Lang; U Till
Related Documents :
6868209 - Cord blood platelet aggregation; quality control by a two-sample technique.
22888009 - A review of the cardiovascular benefits and antioxidant properties of allicin.
3896419 - The effect of a prostaglandin i2 analogue (op-41483) on renal function in burned rabbits.
20050759 - The platelet functions in patients with ankylosing spondylitis: anti-tnf-alpha therapy ...
19192749 - Postoperative surgical chest and leg incision sites using platelet gel: a retrospective...
8344449 - Differential expression of salivary mucin bacterial aggregating activity with caries st...
6416039 - Molecular mechanisms in endotoxin fever.
17954689 - Betulinic acid derivatives that target gp120 and inhibit multiple genetic subtypes of h...
1927699 - Stroke in children.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Chemistry and physics of lipids     Volume:  43     ISSN:  0009-3084     ISO Abbreviation:  Chem. Phys. Lipids     Publication Date:  1987 May 
Date Detail:
Created Date:  1987-09-09     Completed Date:  1987-09-09     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0067206     Medline TA:  Chem Phys Lipids     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  247-55     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Humans
Platelet Activating Factor* / analogs & derivatives,  physiology
Platelet Aggregation*
Structure-Activity Relationship
Chemical
Reg. No./Substance:
0/O-deacetyl platelet activating factor; 0/Platelet Activating Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Hospital disinfection and antibiotic policies.
Next Document:  Spontaneous vesiculation of uncharged phospholipid dispersions consisting of lecithin and lysolecith...