| Modification of lymph by sheep caudal mediastinal node: effect of intranodal endotoxin. | |
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MedLine Citation:
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PMID: 6394565 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Postnodal lymph from the sheep caudal mediastinal node (CMN) is used by many investigators to assess lung vascular protein permeability. We explored the possibility that damage to the CMN blood-lymph barrier could produce increases in postnodal lymph flow and lymph-to-plasma protein concentration ratio (L/P) characteristic of lung vascular damage. Escherichia coli endotoxin (0.049 micrograms/min) was infused into a prenodal lymph vessel to the CMN in the conscious sheep, and postnodal lymph was collected for the next 7 h. Intranodal endotoxin caused an 80% increase in postnodal lymph flow and a 30% increase in postnodal L/P. Because there was no indication that the endotoxin had exerted a systemic effect, the lymph response to endotoxin was attributed to a direct effect of endotoxin on the blood-lymph barrier of the CMN. We conclude that significant increases in postnodal lymph flow and L/P characteristic of lung vascular damage can occur when the blood-lymph barrier of the CMN becomes damaged. |
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Authors:
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T H Adair; J P Montani; A C Guyton |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of applied physiology: respiratory, environmental and exercise physiology Volume: 57 ISSN: 0161-7567 ISO Abbreviation: J Appl Physiol Publication Date: 1984 Nov |
Date Detail:
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Created Date: 1985-02-27 Completed Date: 1985-02-27 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7801242 Medline TA: J Appl Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1597-601 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Proteins / metabolism Endotoxins / pharmacology* Escherichia coli* Female Hemodynamics / drug effects Homeostasis Lymph / metabolism, physiology* Lymph Nodes / drug effects, physiology* Sheep Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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HL-06122/HL/NHLBI NIH HHS; HL-11687/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Blood Proteins; 0/Endotoxins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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