| Modification of lipophilic proteins in Friend erythroleukemia cells during their differentiation. | |
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MedLine Citation:
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PMID: 6945477 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In mouse erythroleukemia cells (MELC) a lipophilic protein of apparent M.W. 9.5 kdaltons increases during differentiation. This increase is due either to an increase of biosynthesis or to a structural alteration impairing the capacity of the protein to form polymers of apparent high M.W. or favoring its extractability. The increases is related to differentiation and precedes hemoglobin synthesis by at least 1 day. It is not related to virus production because it occurs in cells (line F 4-1) which do not produce virus, but it does not occur in cells (TFA-II) in which dimethylsulfoxide (DMSO) causes an increase in virus production. As it occurs in cells treated with 4 different inducers, and as the increase is less marked when antagonists of the inducers are also present, it is unlikely that the increase of the 9.5 Kdalton protein is due to an effect of the inducers unrelated to differentiation. |
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Authors:
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M Semmel; E Delain |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Molecular biology reports Volume: 7 ISSN: 0301-4851 ISO Abbreviation: Mol. Biol. Rep. Publication Date: 1981 Aug |
Date Detail:
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Created Date: 1981-12-21 Completed Date: 1981-12-21 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0403234 Medline TA: Mol Biol Rep Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 247-52 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Differentiation / drug effects Cell Division / drug effects Clone Cells Dimethyl Sulfoxide / pharmacology Friend murine leukemia virus / growth & development Leukemia, Erythroblastic, Acute / metabolism* Leukemia, Experimental / metabolism* Mice Microscopy, Electron Molecular Weight Proteins / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Proteins; 67-68-5/Dimethyl Sulfoxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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