Document Detail

Modification of lipophilic proteins in Friend erythroleukemia cells during their differentiation.
MedLine Citation:
PMID:  6945477     Owner:  NLM     Status:  MEDLINE    
In mouse erythroleukemia cells (MELC) a lipophilic protein of apparent M.W. 9.5 kdaltons increases during differentiation. This increase is due either to an increase of biosynthesis or to a structural alteration impairing the capacity of the protein to form polymers of apparent high M.W. or favoring its extractability. The increases is related to differentiation and precedes hemoglobin synthesis by at least 1 day. It is not related to virus production because it occurs in cells (line F 4-1) which do not produce virus, but it does not occur in cells (TFA-II) in which dimethylsulfoxide (DMSO) causes an increase in virus production. As it occurs in cells treated with 4 different inducers, and as the increase is less marked when antagonists of the inducers are also present, it is unlikely that the increase of the 9.5 Kdalton protein is due to an effect of the inducers unrelated to differentiation.
M Semmel; E Delain
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Molecular biology reports     Volume:  7     ISSN:  0301-4851     ISO Abbreviation:  Mol. Biol. Rep.     Publication Date:  1981 Aug 
Date Detail:
Created Date:  1981-12-21     Completed Date:  1981-12-21     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0403234     Medline TA:  Mol Biol Rep     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  247-52     Citation Subset:  IM    
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MeSH Terms
Cell Differentiation / drug effects
Cell Division / drug effects
Clone Cells
Dimethyl Sulfoxide / pharmacology
Friend murine leukemia virus / growth & development
Leukemia, Erythroblastic, Acute / metabolism*
Leukemia, Experimental / metabolism*
Microscopy, Electron
Molecular Weight
Proteins / metabolism*
Reg. No./Substance:
0/Proteins; 67-68-5/Dimethyl Sulfoxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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