Document Detail

Modification of late epidermal differentiation in photoaged skin treated with topical retinoic acid cream.
MedLine Citation:
PMID:  8520058     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Retinoic acid (RA) cream treatment alters epidermal proliferation and differentiation in photoaged skin. OBJECTIVE: To study the changes in the expression of markers of epidermal differentiation in photoaged skin following RA cream treatment. METHODS: Ten subjects with photoaged skin were examined before treatment and at regular intervals during 12 months of once daily application of 0.05% tretinoin cream over the left forearm. Paraffin-embedded biopsy sections from the forearm were stained with loricrin, filaggrin, involucrin and cornifin antisera in addition to hematoxylin and eosin. The various layers were measured using a calibrated optical micrometer. RESULTS: The thickness of the epidermis increased rapidly, reaching a substantial increase after 1 month of retinoid cream application and retaining it during the following 12 months. The stratum granulosum achieved a transient but substantial increase after 1 and 3 months. Except involucrin, the ratio between the layers expressing the various markers of epidermal differentiation and the epidermis significantly increased following tretinoin cream treatment. CONCLUSION: RA cream treatment not only increases the thickness of the epidermis but also the programming of late terminal epidermal differentiation, as expressed by the markers studied. Thus, RA appears to affect both proliferation and differentiation of keratinocytes in vivo.
E Tur; D Hohl; A Jetten; R Panizzon; E Frenk
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Dermatology (Basel, Switzerland)     Volume:  191     ISSN:  1018-8665     ISO Abbreviation:  Dermatology (Basel)     Publication Date:  1995  
Date Detail:
Created Date:  1996-01-24     Completed Date:  1996-01-24     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9203244     Medline TA:  Dermatology     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  124-8     Citation Subset:  IM    
Department of Dermatology, Tel Aviv Sourasky Medical Center, Tel Aviv University, Israel.
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MeSH Terms
Administration, Topical
Aged, 80 and over
Cell Differentiation / drug effects
Cornified Envelope Proline-Rich Proteins
Epidermis / drug effects*,  metabolism,  pathology
Intermediate Filament Proteins / metabolism
Keratolytic Agents / administration & dosage,  pharmacology*
Membrane Proteins / metabolism
Protein Precursors / metabolism
Skin Aging / drug effects*,  pathology
Tretinoin / administration & dosage,  pharmacology*
Reg. No./Substance:
0/Cornified Envelope Proline-Rich Proteins; 0/Intermediate Filament Proteins; 0/Keratolytic Agents; 0/Membrane Proteins; 0/Protein Precursors; 0/filaggrin; 0/loricrin; 302-79-4/Tretinoin; 60108-77-2/involucrin

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