Document Detail


Modification of fatty acid composition in adipocyte plasma membranes by an oral treatment with a new antidiabetic agent, AS-6, in genetically obese diabetic mice, db/db.
MedLine Citation:
PMID:  3978113     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Male 12-week-old C57BL/KsJ db/db mice were treated for 1 week with a dietary admixture of an experimental antidiabetic agent, AS-6 (4-O-carboxymethylascochlorin, 0.1%). The fatty acid composition of the adipose tissue and its plasma membranes in the treated mice was compared with that in untreated db/db mice and their lean littermates. The results indicate that, when compared with the lean, the db/db adipose tissue and its plasma membrane are extremely rich in nonessential fatty acids, and AS-6 treatment modifies the fatty acyl composition only in the membranes in which 16:1 and 18:1 increase and C18 decreases.
Authors:
T Hosokawa; K Ando; G Tamura
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biochimica et biophysica acta     Volume:  834     ISSN:  0006-3002     ISO Abbreviation:  Biochim. Biophys. Acta     Publication Date:  1985 Mar 
Date Detail:
Created Date:  1985-05-10     Completed Date:  1985-05-10     Revised Date:  2004-11-18    
Medline Journal Info:
Nlm Unique ID:  0217513     Medline TA:  Biochim Biophys Acta     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  130-3     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adipose Tissue / drug effects*
Animals
Cell Membrane / analysis
Diabetes Mellitus / drug therapy
Diabetes Mellitus, Experimental / drug therapy*
Fatty Acids / analysis*
Glycolates / therapeutic use*
Membrane Lipids / analysis*
Mice
Mice, Inbred C57BL
Mice, Obese
Obesity
Chemical
Reg. No./Substance:
0/Fatty Acids; 0/Glycolates; 0/Membrane Lipids; 84435-25-6/4-O-carboxymethylascochlorin

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