Document Detail

Modification of encapsulation pressure of reverse micelles in liquid ethane.
MedLine Citation:
PMID:  21764613     Owner:  NLM     Status:  MEDLINE    
Encapsulation within reverse micelles dissolved in low viscosity fluids offers a potential solution to the slow tumbling problem presented by large soluble macromolecules to solution NMR spectroscopy. The reduction in effective macromolecular tumbling is directly dependent upon the viscosity of the solvent. Liquid ethane is of sufficiently low viscosity at pressures below 5000 psi to offer a significant advantage. Unfortunately, the viscosity of liquid ethane shows appreciable pressure dependence. Reverse micelle encapsulation in liquid ethane often requires significantly higher pressures, which obviates the potential advantages offered by liquid ethane over liquid propane. Addition of co-surfactants or co-solvents can be used to manipulate the minimum pressure required to obtain stable, well-behaved solutions of reverse micelles prepared in liquid ethane. A library of potential additives is examined and several candidates suitable for use with encapsulated proteins are described.
Ronald W Peterson; Nathaniel V Nucci; A Joshua Wand
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2011-07-18
Journal Detail:
Title:  Journal of magnetic resonance (San Diego, Calif. : 1997)     Volume:  212     ISSN:  1096-0856     ISO Abbreviation:  J. Magn. Reson.     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-08-29     Completed Date:  2012-01-05     Revised Date:  2014-09-17    
Medline Journal Info:
Nlm Unique ID:  9707935     Medline TA:  J Magn Reson     Country:  United States    
Other Details:
Languages:  eng     Pagination:  229-33     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
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MeSH Terms
Alcohols / chemistry
Carbon Dioxide / chemistry
Carbon Disulfide / chemistry
Cetrimonium Compounds / chemistry
Cold Temperature
Dioctyl Sulfosuccinic Acid
Ethane / chemistry*
Indicators and Reagents
Proteins / chemistry*
Succinates / chemistry
Surface-Active Agents
Grant Support
GM 087099/GM/NIGMS NIH HHS; GM085120/GM/NIGMS NIH HHS; R01 GM062874/GM/NIGMS NIH HHS; R01 GM062874-03/GM/NIGMS NIH HHS; R01 GM062874-04/GM/NIGMS NIH HHS; R01 GM085120/GM/NIGMS NIH HHS; R01 GM085120-01/GM/NIGMS NIH HHS; R01 GM085120-02/GM/NIGMS NIH HHS; R01 GM085120-03/GM/NIGMS NIH HHS
Reg. No./Substance:
0/Alcohols; 0/Cetrimonium Compounds; 0/Indicators and Reagents; 0/Micelles; 0/Proteins; 0/Solutions; 0/Solvents; 0/Succinates; 0/Surface-Active Agents; 10041-19-7/Dioctyl Sulfosuccinic Acid; 142M471B3J/Carbon Dioxide; L99N5N533T/Ethane; S54S8B99E8/Carbon Disulfide; T75W9911L6/Propane; Z7FF1XKL7A/cetrimonium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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