| Modification of the electrophysiologic matrix by antiarrhythmic drugs. | |
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MedLine Citation:
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PMID: 3923078 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Evidence from many experiments and observations suggests that the likelihood of ventricular fibrillation is increased in some proportion to the magnitude of local differences in the electrophysiologic state of the ventricular myocardium. Many local anesthetic antiarrhythmic drugs have differing affinities for resting, open and inactivated fast channels. In ischemic or otherwise damaged hearts, local differences in resting potential, action potential upstroke and action potential duration will result in differing degrees of block of fast channels by local anesthetic antiarrhythmic drugs. Such drugs can be expected to add to the preexisting local inhomogeneities of electrophysiologic state and thereby increase the likelihood of fibrillation. |
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Authors:
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B F Hoffman |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: Journal of the American College of Cardiology Volume: 5 ISSN: 0735-1097 ISO Abbreviation: J. Am. Coll. Cardiol. Publication Date: 1985 Jun |
Date Detail:
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Created Date: 1985-07-16 Completed Date: 1985-07-16 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8301365 Medline TA: J Am Coll Cardiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 28B-30B Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Action Potentials
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drug effects Anti-Arrhythmia Agents / pharmacology* Arrhythmias, Cardiac / physiopathology* Benzocaine / pharmacology Electrophysiology Heart Conduction System / drug effects Heart Rate / drug effects Humans Lidocaine / analogs & derivatives, pharmacology Time Factors Tocainide Ventricular Fibrillation / physiopathology |
| Grant Support | |
ID/Acronym/Agency:
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HL-08508/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Anti-Arrhythmia Agents; 137-58-6/Lidocaine; 41708-72-9/Tocainide; 94-09-7/Benzocaine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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