| Modification of digital music files for use in human temporary threshold shift studies. | |
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MedLine Citation:
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PMID: 21974483 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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An exposure that is reproducible across clinical/laboratory environments, and appealing to subjects, is described here. Digital music files are level-equated within and across songs such that playlists deliver an exposure that is consistent across time. Modified music is more pleasant to listen to than pure tones or shaped noise, and closely follows music exposures subjects may normally experience. Multiple therapeutics reduce noise-induced hearing loss in animals but human trial design is complicated by limited access to noise-exposed subject populations. The development of standard music exposure parameters for temporary threshold shift studies would allow comparison of protection across agents with real-world relevant stimuli in human subjects. |
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Authors:
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C G Le Prell; Q Yang; J G Harris |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: The Journal of the Acoustical Society of America Volume: 130 ISSN: 1520-8524 ISO Abbreviation: J. Acoust. Soc. Am. Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-10-06 Completed Date: 2012-01-26 Revised Date: 2013-02-08 |
Medline Journal Info:
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Nlm Unique ID: 7503051 Medline TA: J Acoust Soc Am Country: United States |
Other Details:
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Languages: eng Pagination: EL142-6 Citation Subset: IM |
Copyright Information:
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© 2011 Acoustical Society of America |
Affiliation:
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Department of Speech, Language, and Hearing Sciences, University of Florida, Gainesville, Florida 32608, USA. colleeng@ufl.edu |
| Data Bank Information | |
Bank Name/Acc. No.:
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ClinicalTrials.gov/NCT00808470 |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acoustic Stimulation
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instrumentation,
methods* Auditory Threshold* Ear Protective Devices Hearing Loss, Noise-Induced / physiopathology, prevention & control Humans MP3-Player Music* Reproducibility of Results Research Design Sound Spectrography Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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U01 DC 008423/DC/NIDCD NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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