Document Detail

Modification of digital music files for use in human temporary threshold shift studies.
MedLine Citation:
PMID:  21974483     Owner:  NLM     Status:  MEDLINE    
An exposure that is reproducible across clinical/laboratory environments, and appealing to subjects, is described here. Digital music files are level-equated within and across songs such that playlists deliver an exposure that is consistent across time. Modified music is more pleasant to listen to than pure tones or shaped noise, and closely follows music exposures subjects may normally experience. Multiple therapeutics reduce noise-induced hearing loss in animals but human trial design is complicated by limited access to noise-exposed subject populations. The development of standard music exposure parameters for temporary threshold shift studies would allow comparison of protection across agents with real-world relevant stimuli in human subjects.
C G Le Prell; Q Yang; J G Harris
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  The Journal of the Acoustical Society of America     Volume:  130     ISSN:  1520-8524     ISO Abbreviation:  J. Acoust. Soc. Am.     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-10-06     Completed Date:  2012-01-26     Revised Date:  2014-04-01    
Medline Journal Info:
Nlm Unique ID:  7503051     Medline TA:  J Acoust Soc Am     Country:  United States    
Other Details:
Languages:  eng     Pagination:  EL142-6     Citation Subset:  IM    
Copyright Information:
© 2011 Acoustical Society of America
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MeSH Terms
Acoustic Stimulation / instrumentation,  methods*
Auditory Threshold*
Ear Protective Devices
Hearing Loss, Noise-Induced / physiopathology,  prevention & control
Reproducibility of Results
Research Design
Sound Spectrography
Time Factors
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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