Document Detail


Modification of the descending thoracic aortic anastomotic site using biodegradable felt: study in a canine model with or without basic fibroblast growth factor.
MedLine Citation:
PMID:  19914025     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: We investigated the outcomes of reinforcing anastomotic sites using (1) nonbiodegradable polytetrafluoroethylene (PTFE) felt, (2) biodegradable polyglycolic acid (PGA) felt, and (3) PGA felt with basic fibroblast growth factor (bFGF) in a canine descending thoracic aortic replacement model.
METHODS: Thirty-seven beagles underwent descending thoracic aorta replacement using a prosthetic graft with one of the above-mentioned reinforcements or no reinforcement for controls. Histologic evaluations were carried out 1 month and 3 months after surgery. The biomechanical strength of the anastomosis was assessed along the longitudinal axis of the aortic segments using a tensile tester. Local compliance at the anastomotic site was also evaluated in the circumferential direction.
RESULTS: The media was significantly thinner in the PTFE group than in the control group (65.8% +/- 5.1% vs 95.0% +/- 9.3% of normal thickness; P < .05). Relative to the control group, the adventitial layer was significantly thinner in the PTFE group (42.3% +/- 8.2% of control; P < .05) but significantly thicker in the PGA and the PGA + bFGF groups (117.2% +/- 11.3% and 134.1% +/- 14.2% of control, respectively; P < .05). There were more vessels in the adventitial layer in the PGA + bFGF group than in the control, PTFE, and PGA groups (29.2 +/- 2.1/mm(2) vs 13.8 +/- 0.8, 5.4 +/- 0.7, 17.0 +/- 1.3/mm(2), respectively; P < .01). There were no significant differences between the four groups in the failure force at anastomotic sites. Local compliance at the anastomotic site was higher in the PGA group than that in the PTFE group (11.6 +/- 1.6 10(-6) m(2)/N vs 5.6 +/- 1.9 10(-6) m(2)/N; P < .05).
CONCLUSION: Reinforcement of the experimental aortic wall with PTFE felt resulted in thinning of the media and adventitia and fewer vessels at the anastomotic site. These histologic changes were not observed when biodegradable felt was used. The bFGF failed to augment the modification of the aortic wall with the exception of increased adventitial vessel number. Biomechanical strength of the anastomosis along the longitudinal axis was comparable in all four groups; however, local vascular compliance was better in the biodegradable PGA felt group.
Authors:
Hidenori Fujiwara; Yoshikatsu Saiki; Mitsuru Sato; Naoya Sakamoto; Toshiro Ohashi; Masaaki Sato; Yasuhiko Tabata; Koichi Tabayashi
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Publication Detail:
Type:  Journal Article     Date:  2009-11-13
Journal Detail:
Title:  Journal of vascular surgery     Volume:  51     ISSN:  1097-6809     ISO Abbreviation:  J. Vasc. Surg.     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-02-01     Completed Date:  2010-02-23     Revised Date:  2012-10-03    
Medline Journal Info:
Nlm Unique ID:  8407742     Medline TA:  J Vasc Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  194-202     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Society for Vascular Surgery. Published by Mosby, Inc. All rights reserved.
Affiliation:
Department of Cardiovascular Surgery, Graduate School of Medicine, Tohoku University, Sendai, Japan.
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MeSH Terms
Descriptor/Qualifier:
Absorbable Implants*
Anastomosis, Surgical
Animals
Aorta, Thoracic / drug effects,  pathology,  surgery*
Biomechanics
Blood Vessel Prosthesis*
Blood Vessel Prosthesis Implantation / instrumentation*
Compliance
Connective Tissue / blood supply,  drug effects,  surgery
Dogs
Drug Carriers
Equipment Failure Analysis
Fibroblast Growth Factor 2 / administration & dosage*
Materials Testing
Models, Animal
Muscle, Smooth, Vascular / drug effects,  pathology,  surgery
Polyglycolic Acid*
Polytetrafluoroethylene*
Prosthesis Design
Prosthesis Failure
Tensile Strength
Tunica Media / drug effects,  pathology,  surgery
Wound Healing / drug effects*
Chemical
Reg. No./Substance:
0/Drug Carriers; 103107-01-3/Fibroblast Growth Factor 2; 26009-03-0/Polyglycolic Acid; 9002-84-0/Polytetrafluoroethylene

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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