Document Detail


Modification of cord blood IL-6 production with IgM enriched human immunoglobulin in term and preterm infants.
MedLine Citation:
PMID:  15016408     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Pro-inflammatory cytokines contribute significantly to the morbidity of premature infants. IL-6 and IL-8 are involved in the pathogenesis of pulmonary and cerebral tissue injury. The effect of human immunoglobulin preparations on cytokine production in preterm infants has not been studied. We investigated the influence of immunoglobulin on LPS stimulated IL-6 and IL-8 production in cord blood of healthy preterm neonates. Ten non-infected preterm infants delivered by cesarean section and 5 healthy term neonates were included. In the preterm infants, significant IL-6 production was observed in the absence of immunoglobulin after 4 h [median 113 (39-725) pg/ml], 8 h [375 (234-1795) pg/ml] and 12 h [360 (248-2765) pg/ml] of LPS incubation. IL-6 concentrations were significantly lower after incubation with LPS+immunoglobulin after 4 h [median 38 (5-568) pg/ml; p=0.005], 8 h [178 (10-1830) pg/ml; p=0.001] and 12 h [182 (29-2530) pg/ml; p=0.002]. Cultures from term infants produced IL-6 levels approx. 4 times of those from premature infants unaffected by immunoglobulin. IL-8 production also correlated to gestational age and was not affected by immunoglobulin in both groups. Human immunoglobulin preparation may modify IL-6 production in cord blood cultures from premature infants.
Authors:
J Dembinski; R Martini; D Behrendt; P Bartmann
Related Documents :
3966198 - Evidence of hyperinsulinaemia and hypoxaemia in the cord blood of neonates born to moth...
6259578 - Adrenal cortical function in the postmature fetus and newborn infant.
15507968 - Umbilical cord plasma interleukin-6 concentrations in preterm infants and risk of neona...
7457518 - Maternal and cord blood complement activity: relationship to premature rupture of the m...
21238638 - Decreased cerebral oxygen saturation during thoracoscopic repair of congenital diaphrag...
20653398 - The cost effectiveness of palivizumab: a systematic review of the evidence.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cytokine     Volume:  26     ISSN:  1043-4666     ISO Abbreviation:  Cytokine     Publication Date:  2004 Apr 
Date Detail:
Created Date:  2004-03-12     Completed Date:  2004-12-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9005353     Medline TA:  Cytokine     Country:  United States    
Other Details:
Languages:  eng     Pagination:  25-9     Citation Subset:  IM    
Affiliation:
Department of Neonatology, Center of Pediatrics, University of Bonn, Adenauerallee 119, D-53113 Bonn, Germany. j.dembinski@zhsdirksland.nl
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Cells, Cultured
Cesarean Section
Fetal Blood / metabolism*
Humans
Immunoglobulin M / immunology*
Infant, Newborn
Infant, Premature / blood,  immunology*
Interleukin-6 / biosynthesis,  immunology*
Interleukin-8 / biosynthesis,  immunology
Lipopolysaccharides / pharmacology
Chemical
Reg. No./Substance:
0/Immunoglobulin M; 0/Interleukin-6; 0/Interleukin-8; 0/Lipopolysaccharides

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  TNF-alpha promoter, Nod2 and toll-like receptor-4 polymorphisms and the in vivo and ex vivo response...
Next Document:  Middle ear epithelial mucin production in response to interleukin-6 exposure in vitro.