Document Detail

Modification of cord blood IL-6 production with IgM enriched human immunoglobulin in term and preterm infants.
MedLine Citation:
PMID:  15016408     Owner:  NLM     Status:  MEDLINE    
Pro-inflammatory cytokines contribute significantly to the morbidity of premature infants. IL-6 and IL-8 are involved in the pathogenesis of pulmonary and cerebral tissue injury. The effect of human immunoglobulin preparations on cytokine production in preterm infants has not been studied. We investigated the influence of immunoglobulin on LPS stimulated IL-6 and IL-8 production in cord blood of healthy preterm neonates. Ten non-infected preterm infants delivered by cesarean section and 5 healthy term neonates were included. In the preterm infants, significant IL-6 production was observed in the absence of immunoglobulin after 4 h [median 113 (39-725) pg/ml], 8 h [375 (234-1795) pg/ml] and 12 h [360 (248-2765) pg/ml] of LPS incubation. IL-6 concentrations were significantly lower after incubation with LPS+immunoglobulin after 4 h [median 38 (5-568) pg/ml; p=0.005], 8 h [178 (10-1830) pg/ml; p=0.001] and 12 h [182 (29-2530) pg/ml; p=0.002]. Cultures from term infants produced IL-6 levels approx. 4 times of those from premature infants unaffected by immunoglobulin. IL-8 production also correlated to gestational age and was not affected by immunoglobulin in both groups. Human immunoglobulin preparation may modify IL-6 production in cord blood cultures from premature infants.
J Dembinski; R Martini; D Behrendt; P Bartmann
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cytokine     Volume:  26     ISSN:  1043-4666     ISO Abbreviation:  Cytokine     Publication Date:  2004 Apr 
Date Detail:
Created Date:  2004-03-12     Completed Date:  2004-12-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9005353     Medline TA:  Cytokine     Country:  United States    
Other Details:
Languages:  eng     Pagination:  25-9     Citation Subset:  IM    
Department of Neonatology, Center of Pediatrics, University of Bonn, Adenauerallee 119, D-53113 Bonn, Germany.
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MeSH Terms
Cells, Cultured
Cesarean Section
Fetal Blood / metabolism*
Immunoglobulin M / immunology*
Infant, Newborn
Infant, Premature / blood,  immunology*
Interleukin-6 / biosynthesis,  immunology*
Interleukin-8 / biosynthesis,  immunology
Lipopolysaccharides / pharmacology
Reg. No./Substance:
0/Immunoglobulin M; 0/Interleukin-6; 0/Interleukin-8; 0/Lipopolysaccharides

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