Document Detail

Modification of the circadian variation of symptom onset of acute myocardial infarction in diabetes mellitus.
MedLine Citation:
PMID:  7788037     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The effects of diabetes mellitus and its treatment on the circadian variation of symptom onset in acute myocardial infarction were examined. METHODS: We obtained the time of symptom onset in 336 patients who had suffered acute myocardial infarction. RESULTS: As in earlier studies, the peak of symptom onset occurred in the late morning, between 6:01 a.m. and 12:00 noon. Although a similar circadian variation was observed in non-diabetic patients, the late-morning peak was less prominent in diabetic patients. In diabetic patients receiving treatment, however, the circadian pattern was well preserved, whereas in untreated diabetic patients there were no peaks in the distribution of symptom onset of acute myocardial infarction. CONCLUSION: These findings suggest that autonomic disturbances in diabetes mellitus may blunt the late-morning peak in the frequency of onset of acute myocardial infarction.
T Tanaka; M Fujita; T Fudo; S Tamaki; R Nohara; S Sasayama
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Coronary artery disease     Volume:  6     ISSN:  0954-6928     ISO Abbreviation:  Coron. Artery Dis.     Publication Date:  1995 Mar 
Date Detail:
Created Date:  1995-07-26     Completed Date:  1995-07-26     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9011445     Medline TA:  Coron Artery Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  241-4     Citation Subset:  IM    
Takeda Hospital, College of Medical Technology, Japan.
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MeSH Terms
Circadian Rhythm*
Diabetes Complications*
Middle Aged
Myocardial Infarction / complications*,  diagnosis

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