Document Detail


Modification of cell evagination and cell differentiation in quail oviduct hyperstimulated by progesterone.
MedLine Citation:
PMID:  2631979     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Quail oviduct development is controlled by sex steroid hormones. Estrogen (E) induce cell proliferation, formation of tubular glands by epithelial cell evagination and cell differentiation. Progesterone (P) strongly increases the secretory process in E-treated quails, but inhibits cell proliferation, cell evagination and differentiation of ciliated cells. The balance between E and P is critical for harmonious development of the oviduct. After 6 daily injections of two doses of estradiol benzoate (10 or 20 micrograms/d) and high doses of P (4 mg/d), tubular gland formation by epithelial cell evagination was inhibited, while epithelial cell proliferation occurred, as shown by the height of the villi and the increase in DNA. Secretory processes were strongly stimulated. Ovalbumin, a tubular gland cell marker and avidin, a mucous cell marker, were localized by immunofluorescence and immunogold labeling. Ovalbumin was localized only in the rudimentary tubular glands, whereas avidin was dispersed throughout the secretory cells. High doses of progesterone inhibited tubular gland cell proliferation, disturbed the distribution of avidin and inhibited differentiation of ciliated cells. Ovalbumin synthesis occurred only in epithelial cells which were evaginated despite the hyperstimulation. Ovalbumin gene expression appeared highly dependent upon the cell position.
Authors:
O Perche; M C Lainé; J F Pageaux; C Laugier; D Sandoz
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biology of the cell / under the auspices of the European Cell Biology Organization     Volume:  67     ISSN:  0248-4900     ISO Abbreviation:  Biol. Cell     Publication Date:  1989  
Date Detail:
Created Date:  1990-05-15     Completed Date:  1990-05-15     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8108529     Medline TA:  Biol Cell     Country:  FRANCE    
Other Details:
Languages:  eng     Pagination:  123-34     Citation Subset:  IM    
Affiliation:
Centre de Biologie Cellulaire CNRS, Ivry, France.
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MeSH Terms
Descriptor/Qualifier:
Animals
Avidin / analysis
Body Weight
Cell Differentiation / physiology
Coturnix
Estradiol / pharmacology
Estrogens / physiology
Female
Immunohistochemistry
Organ Size
Ovalbumin / analysis
Oviducts / cytology,  growth & development*,  ultrastructure
Progesterone / administration & dosage,  pharmacology,  physiology*
Chemical
Reg. No./Substance:
0/Estrogens; 1405-69-2/Avidin; 50-28-2/Estradiol; 57-83-0/Progesterone; 9006-59-1/Ovalbumin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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