| Modification by glibenclamide of the electrophysiological consequences of myocardial ischaemia in dogs and rabbits. | |
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MedLine Citation:
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PMID: 2122259 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Glibenclamide has been shown to block ATP-dependent K+ channels in the heart and prevent the shortening of cardiac action potentials caused by hypoxia in vitro. The present study examines the ability of glibenclamide to modify the effect of acute ischaemia on monophasic action potential duration in pentobarbital-anaesthetized rabbits, and on monophasic action potential duration and ventricular fibrillation threshold in pentobarbital-anaesthetized dogs. Left ventricular endocardial monophasic action potential duration was measured using a contact electrode catheter, and ventricular fibrillation threshold was measured by the single pulse method. Ischaemia was produced in rabbits by occluding the circumflex coronary for 5 min and in dogs by occluding the left anterior descending coronary artery for 40 min. In rabbits, glibenclamide (0.3-3 mg/kg, i.v.) had no effect on baseline monophasic action potential duration, but attenuated action potential shortening during ischaemia in a dose-related manner. In dogs, monophasic action potential duration did not shorten during ischaemia in the vehicle group, but tended to increase in the glibenclamide group (0.5 mg/kg, i.v.) both before and during ischaemia (7 +/- 5% and 14 +/- 8%, respectively, NS). Likewise, ventricular effective refractory period was significantly increased by glibenclamide prior to ischaemia (5 +/- 1%). Ventricular fibrillation threshold tended to increase during 40 min of ischaemia in vehicle-treated dogs (40 +/- 29%, NS), but was unchanged during ischaemia in the glibenclamide-treated dogs.(ABSTRACT TRUNCATED AT 250 WORDS) |
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Authors:
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J K Smallwood; P J Ertel; M I Steinberg |
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Publication Detail:
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Type: In Vitro; Journal Article |
Journal Detail:
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Title: Naunyn-Schmiedeberg's archives of pharmacology Volume: 342 ISSN: 0028-1298 ISO Abbreviation: Naunyn Schmiedebergs Arch. Pharmacol. Publication Date: 1990 Aug |
Date Detail:
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Created Date: 1990-12-27 Completed Date: 1990-12-27 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0326264 Medline TA: Naunyn Schmiedebergs Arch Pharmacol Country: GERMANY |
Other Details:
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Languages: eng Pagination: 214-20 Citation Subset: IM |
Affiliation:
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Department of Cardiovascular Pharmacology, Lilly Research Laboratories, Eli Lilly and Co., Indianapolis, Indiana 46285. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Action Potentials
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drug effects Animals Blood Pressure / drug effects Coronary Disease / physiopathology* Coronary Vessels / physiopathology Dogs Electrophysiology Female Glyburide / pharmacology* Male Muscle, Smooth, Vascular / drug effects Purkinje Fibers / drug effects Rabbits Ventricular Fibrillation / physiopathology |
| Chemical | |
Reg. No./Substance:
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10238-21-8/Glyburide |
| Comments/Corrections | |
Erratum In:
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Naunyn Schmiedebergs Arch Pharmacol 1990 Dec;342(6):726 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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