Document Detail

Modification by alfentanil of the haemodynamic response to tracheal intubation in elderly patients. A dose-response study.
MedLine Citation:
PMID:  3128318     Owner:  NLM     Status:  MEDLINE    
Fifty-five elderly patients undergoing elective ophthalmological surgery were randomly allocated to four groups. Following the induction of anaesthesia with thiopentone (given over 2 min) and the administration of atracurium 0.6 mg kg-1, patients received alfentanil 400, 600, 800 or 1000 micrograms. Intubation of the trachea was performed 90 s later. Heart rate was monitored continuously and systolic arterial pressure was measured at 1-min intervals for 3 min before induction, and both variables were monitored until 10 min had elapsed after tracheal intubation. In each of the groups there was a significant decrease in systolic arterial pressure and a significant increase in heart rate on induction of anaesthesia. In those patients who received either 400 or 600 micrograms of alfentanil, arterial pressure increased immediately after tracheal intubation, whereas in those receiving alfentanil 800 or 1000 micrograms, arterial pressure decreased immediately after tracheal intubation, and when measured 10 min after intubation. It is suggested that alfentanil 600 micrograms (10 micrograms kg-1) constitutes the optimal dose with which to obtund the haemodynamic response to tracheal intubation in elderly patients, and to minimize cardiovascular depression after tracheal intubation.
I J Kirby; D Northwood; M E Dodson
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  British journal of anaesthesia     Volume:  60     ISSN:  0007-0912     ISO Abbreviation:  Br J Anaesth     Publication Date:  1988 Mar 
Date Detail:
Created Date:  1988-05-25     Completed Date:  1988-05-25     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0372541     Medline TA:  Br J Anaesth     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  384-7     Citation Subset:  IM    
Royal Liverpool Hospital.
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MeSH Terms
Adjuvants, Anesthesia / administration & dosage,  pharmacology*
Blood Pressure / drug effects
Dose-Response Relationship, Drug
Fentanyl / administration & dosage,  analogs & derivatives*,  pharmacology
Heart Rate / drug effects
Hemodynamics / drug effects*
Intubation, Intratracheal*
Prospective Studies
Reg. No./Substance:
0/Adjuvants, Anesthesia; 437-38-7/Fentanyl; 71195-58-9/Alfentanil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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