Document Detail

Modification of the behavioural effects of amineptine after acute, subacute and chronic administration of phenobarbital in mice.
MedLine Citation:
PMID:  2519874     Owner:  NLM     Status:  MEDLINE    
In an open-field test, mice that were given an acute treatment with 20 mg/kg ip phenobarbital and/or 10-20 mg/kg ip amineptine showed an increase in locomotor activity and rearing. Tolerance to the subacute or chronic effects of phenobarbital, but not to those of amineptine, was found. After subacute or chronic treatment with phenobarbital in association with amineptine, a significant decrease in the stimulating effect of amineptine was observed, as compared to single or associated acute treatments. These data demonstrate that, after subacute or chronic administration of phenobarbital and amineptine, an interaction occurs, and they outline the importance of enzyme induction in the metabolism of amineptine.
L De Angelis
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  In vivo (Athens, Greece)     Volume:  3     ISSN:  0258-851X     ISO Abbreviation:  In Vivo     Publication Date:    1989 Sep-Oct
Date Detail:
Created Date:  1992-03-09     Completed Date:  1992-03-09     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8806809     Medline TA:  In Vivo     Country:  GREECE    
Other Details:
Languages:  eng     Pagination:  331-4     Citation Subset:  IM    
Istituto di Farmacologia, Facoltà di Medicina e Chirurgia, Università di Trieste, Italy.
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MeSH Terms
Aggression / drug effects*
Analysis of Variance
Antidepressive Agents, Tricyclic / pharmacology*
Dibenzocycloheptenes / pharmacology*
Drug Administration Schedule
Drug Interactions
Injections, Intraperitoneal
Mice, Inbred Strains
Motor Activity / drug effects*
Phenobarbital / pharmacology*
Reference Values
Reg. No./Substance:
0/Antidepressive Agents, Tricyclic; 0/Dibenzocycloheptenes; 50-06-6/Phenobarbital; 57574-09-1/amineptin

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