| Modification of alginate degradation properties using orthosilicic acid. | |
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MedLine Citation:
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PMID: 22301188 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Biopolymers such as alginates have been widely researched for clinical use. Their clinical application, however, have been limited due to their unpredictable and often rapid degradation rates. Here we show that the degradation of an alginate hydrogel can be tailored through the addition of orthosilicic acid (OSA). On immersion in aqueous media a negligible quantity of orthosilicic acid was released from the gel matrix. The presence of the OSA within the gel was shown to significantly slow degradation of the alginate hydrogel when immersed in a potent calcium chelator (EDTA) when compared with the control group. Sample degradation was associated with a significant calcium release from the non-modified gel; however, the orthosilicic acid modified gel did not release detectable levels of calcium over the same period. This suggests that the orthosilicic acid inhibits degradation of the gel by forming an interaction with the calcium cross-links. A rapid reduction in the storage modulus G', was observed in alginate made without OSA, however, the G'exhibited by the orthosilicic acid modified alginate did not reduce significantly (p<0.05). Furthermore, although both the OSA and alginate exhibit negative charges in solution, it is likely that they form weak interactions, this hypothesis was proven by demonstrating the efficacy of OSA for binding the alginate hydrocolloid. The findings of this study are likely to have utility in applications where controlling gel degradation is desirable, such as in cell delivery or in the controlled release of molecules in the body. |
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Authors:
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Gurpreet Birdi; Rachel H Bridson; Alan M Smith; Siti Pauliena Mohd Bohari; Liam M Grover |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-10-18 |
Journal Detail:
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Title: Journal of the mechanical behavior of biomedical materials Volume: 6C ISSN: 1878-0180 ISO Abbreviation: - Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-2-3 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101322406 Medline TA: J Mech Behav Biomed Mater Country: - |
Other Details:
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Languages: ENG Pagination: 181-187 Citation Subset: - |
Copyright Information:
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Copyright © 2011 Elsevier Ltd. All rights reserved. |
Affiliation:
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School of Chemical Engineering, University of Birmingham, B15 2TT, UK. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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