| Modification of the action of misonidazole. I. Effect of TAN on toxicity. | |
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MedLine Citation:
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PMID: 6968295 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The toxicity of misonidazole, an electron affinic radiosensitizer, is greatly reduced by TAN, a free radical radiosensitizer. The production of single-strand breaks in DNA of mammalian cells incubated in dilute suspension with misonidazole (15 mM) under hypoxic conditions is greatly decreased by the presence of TAN (10 mM). The survival of such cells is also greatly enhanced if TAN is present at a concentration of 10mM even less. The implications and possible mechanisms of this finding are discussed. |
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Authors:
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K A Skov; B Palcic; I E Harrison; L D Skarsgard |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: International journal of radiation biology and related studies in physics, chemistry, and medicine Volume: 37 ISSN: 0020-7616 ISO Abbreviation: Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med. Publication Date: 1980 Jun |
Date Detail:
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Created Date: 1980-12-18 Completed Date: 1980-12-18 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0374725 Medline TA: Int J Radiat Biol Relat Stud Phys Chem Med Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 601-11 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Line Cell Survival / drug effects* Cricetinae Cricetulus Cyclic N-Oxides / pharmacology* DNA / metabolism Drug Interactions Misonidazole / toxicity* Nitroimidazoles / toxicity* Oxygen Time Factors Triacetoneamine-N-Oxyl / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Cyclic N-Oxides; 0/Nitroimidazoles; 13551-87-6/Misonidazole; 2896-70-0/Triacetoneamine-N-Oxyl; 7782-44-7/Oxygen; 9007-49-2/DNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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