| Modification of Msx1 by SUMO-1. | |
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MedLine Citation:
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PMID: 16678795 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The small ubiquitin-related modifier SUMO reversibly modifies many proteins, including promoter-specific transcription factors. Genetic studies in both humans and mice indicate that the Msx1 transcription factor is associated with specific disorders, including cleft palate. We show that Msx1 conjugation to SUMO-1 in vivo is enhanced by an E3 SUMO ligase, PIAS1, suggesting that sumoylation of Msx1 is a new mechanism for modulating the molecular function of Msx1 during organogenesis. |
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Authors:
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Vandana Gupta; Marianna Bei |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2006-04-19 |
Journal Detail:
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Title: Biochemical and biophysical research communications Volume: 345 ISSN: 0006-291X ISO Abbreviation: Biochem. Biophys. Res. Commun. Publication Date: 2006 Jun |
Date Detail:
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Created Date: 2006-05-17 Completed Date: 2006-07-11 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0372516 Medline TA: Biochem Biophys Res Commun Country: United States |
Other Details:
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Languages: eng Pagination: 74-7 Citation Subset: IM |
Affiliation:
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Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, 149, 13th Street, Charlestown, MA 02129, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Binding Sites Cells, Cultured MSX1 Transcription Factor / chemistry*, metabolism* Mice Mice, Inbred C3H Organogenesis / physiology* Protein Binding SUMO-1 Protein / chemistry*, metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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K22 DE 14230/DE/NIDCR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/MSX1 Transcription Factor; 0/Msx1 protein, mouse; 0/SUMO-1 Protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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