| Modic type I change may predict rapid progressive, deforming disc degeneration: a prospective 1-year follow-up study. | |
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MedLine Citation:
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PMID: 22249308 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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INTRODUCTION: This prospective magnetic resonance imaging (MRI) study in chronic low-back pain (CLBP) patients evaluated the natural course of degenerative lumbar spine changes in relation to Modic 1 type changes (M1) within 1 year. MATERIALS AND METHODS: From 3,811 consecutive CLBP patients referred to lumbar spine MRI 54 patients with a large M1 were selected using strict exclusion criteria to exclude specific back disorders. Follow-up MRI was obtained within 11-18 months. RESULTS: At baseline M1 was associated with an adjacent endplate lesion in 96% of the cases. In follow-up, an unstable M1 was associated both with an increase of endplate lesions, decrease of disc height and change in disc signal intensity, most found at L4/5 or L5/S1. In disc spaces without M1, progression of degenerative changes was rare. CONCLUSION: Endplate deformation, decreasing disc height and change of disc signal intensity appear essential features of accelerated degenerative process associated with M1. |
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Authors:
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Liisa Kerttula; Katariina Luoma; Tapio Vehmas; Mats Grönblad; Eeva Kääpä |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-17 |
Journal Detail:
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Title: European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society Volume: - ISSN: 1432-0932 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-17 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9301980 Medline TA: Eur Spine J Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Radiology, Helsinki University Central Hospital, Topeliuksenkatu 5, HUS, 00029, Helsinki, Finland, liisa.kerttula@hus.fi. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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