Document Detail

Modes of action of gallic acid in suppressing food intake of rats.
MedLine Citation:
PMID:  7299491     Owner:  NLM     Status:  MEDLINE    
Gallic acid (3,4,5,trihydroxybenzoic acid) is a naturally occurring polyphenol comprising the major hydrolytic product of tannic acid. Gallic acid and tannic acid were previously shown to suppress food intake of animals to a similar extent. However, the mechanism by which this effect takes place has not been previously reported. Reported here is that the effect of gallic acid on food intake is not mediated entirely through taste aversion or through other gastrointestinal factors, since a continuous daily infusion of a gallic acid solution (18 ml; 2%) resulted in a significant reduction of food intake. The catechol moiety of gallic acid plays an important role in its suppression of food intake since administration of tis 4-0 methyl derivative was significantly less effective is suppressing food intake (P less than 0.01). The effectiveness of gallic acid in suppressing food intake diminishes with time, indicating adaptation to the consumption of this polyphenol. Propyl gallate is a more potent suppressor of food intake than gallic acid. Adaptation to the consumption of this polyphenol, it it exists at all, is much slower than with gallic.
Z Glick
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of nutrition     Volume:  111     ISSN:  0022-3166     ISO Abbreviation:  J. Nutr.     Publication Date:  1981 Nov 
Date Detail:
Created Date:  1982-01-09     Completed Date:  1982-01-09     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0404243     Medline TA:  J Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1910-6     Citation Subset:  IM    
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MeSH Terms
Body Weight / drug effects
Eating / drug effects*
Gallic Acid / pharmacology*
Intubation, Gastrointestinal
Propyl Gallate / pharmacology
Rats, Inbred Strains
Structure-Activity Relationship
Grant Support
Reg. No./Substance:
121-79-9/Propyl Gallate; 149-91-7/Gallic Acid

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