Document Detail

Modern concepts in the biology, diagnosis, differential diagnosis and treatment of primary central nervous system lymphoma.
MedLine Citation:
PMID:  21818113     Owner:  NLM     Status:  MEDLINE    
Recent studies addressing the molecular characteristics of PCNSL, which is defined as malignant B-cell lymphoma with morphological features of DLBCL, have significantly improved our understanding of the pathogenesis of this lymphoma entity, which is associated with an inferior prognosis as compared with DLBCL outside the CNS. This unfavorable prognosis stimulated intense efforts to improve therapy and induced recent series of clinical studies, which addressed the role of radiotherapy and various chemotherapeutic regimens. This review combines the discussion of diagnosis, differential diagnosis and recent progress in studies addressing the molecular pathogenesis as well as therapeutic options in PCNSL.
M Deckert; A Engert; W Brück; A J M Ferreri; J Finke; G Illerhaus; W Klapper; A Korfel; R Küppers; M Maarouf; M Montesinos-Rongen; W Paulus; U Schlegel; H Lassmann; O D Wiestler; R Siebert; L M DeAngelis
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2011-08-05
Journal Detail:
Title:  Leukemia     Volume:  25     ISSN:  1476-5551     ISO Abbreviation:  Leukemia     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-12-14     Completed Date:  2012-01-31     Revised Date:  2013-03-04    
Medline Journal Info:
Nlm Unique ID:  8704895     Medline TA:  Leukemia     Country:  England    
Other Details:
Languages:  eng     Pagination:  1797-807     Citation Subset:  IM    
Department of Neuropathology, University Hospital of Cologne, Cologne, Germany.
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MeSH Terms
Central Nervous System Neoplasms / diagnosis*,  genetics*,  therapy*

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