| Moderate weight loss depletes intramyocellular triglycerides but has no effect on diglycerides in type II diabetes. | |
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MedLine Citation:
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PMID: 20087374 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Intramyocellular diglycerides have been implicated in the development of insulin resistance. We aimed to evaluate the effect of weight loss, a well-known means for the improvement of insulin resistance, on intramyocellular diglycerides and triglycerides in type II diabetes. Participants were five obese women with type II diabetes (body mass index 37.5+/-1.9 kg/m(2)), who participated in a weight loss program. The aim of the program was a reduction in body weight by 10%. Muscle biopsies were obtained before and after weight loss. The intervention induced a marked reduction in intramyocellular triglycerides by 77.7+/-13.1%, whereas no significant differences were observed for diglycerides before and after weight loss. Our results indicate that weight loss due to negative energy balance depletes intramyocellular lipid storage without affecting intermediate molecules of lipid metabolism, such as intramyocellular diglycerides. |
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Authors:
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C A Anastasiou; S A Kavouras; Y Lentzas; A Gova; L S Sidossis; A Melidonis |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-01-20 |
Journal Detail:
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Title: European journal of clinical nutrition Volume: 64 ISSN: 1476-5640 ISO Abbreviation: Eur J Clin Nutr Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-03-03 Completed Date: 2010-05-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8804070 Medline TA: Eur J Clin Nutr Country: England |
Other Details:
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Languages: eng Pagination: 328-30 Citation Subset: IM |
Affiliation:
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Laboratory of Nutrition and Clinical Dietetics, Department of Dietetics and Nutrition, Harokopio University, Athens, Greece. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Body Mass Index Diabetes Mellitus, Type 2 / diet therapy, metabolism* Diglycerides / analysis, metabolism* Female Glucose Tolerance Test Humans Insulin Resistance / physiology* Middle Aged Muscle Cells / chemistry, metabolism* Muscle, Skeletal / chemistry, cytology, metabolism Obesity / diet therapy, metabolism Triglycerides / analysis, metabolism* Weight Loss / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Diglycerides; 0/Triglycerides |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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