| Moderate use of alcohol, tobacco and cannabis during pregnancy: new approaches and update on research findings. | |
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MedLine Citation:
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PMID: 19394419 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Interest in fetal origins of adverse offspring outcomes has grown extensively in the last decade. This has resulted in many published studies focusing on exposure in utero to substances and human offspring outcomes. Exposure to maternal substance use in pregnancy is believed to be a preventable hazard, and is therefore a main issue for public health concern and policy. However, an important question in human studies remains whether prenatal substance use exposure has an aetiological role in pathways to adverse developmental and behavioural outcomes via teratological effects. Recent insights and developments in research methodology will aid the adequate and more refined testing of associations between prenatal substance use and offspring outcomes. In particular, novel approaches could assist in disentangling the exposure to substance effects from correlated risk factors. The purpose of this manuscript is therefore to provide an overview of methodological issues involved in studies that focus on the association between maternal substance use during pregnancy and offspring's outcomes, to describe novel approaches to test these associations, and present some examples of new and well-designed studies and discuss their findings. |
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Authors:
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Anja C Huizink |
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Publication Detail:
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Type: Journal Article; Review Date: 2009-04-24 |
Journal Detail:
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Title: Reproductive toxicology (Elmsford, N.Y.) Volume: 28 ISSN: 1873-1708 ISO Abbreviation: Reprod. Toxicol. Publication Date: 2009 Sep |
Date Detail:
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Created Date: 2009-07-27 Completed Date: 2009-09-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8803591 Medline TA: Reprod Toxicol Country: United States |
Other Details:
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Languages: eng Pagination: 143-51 Citation Subset: IM |
Affiliation:
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Department of Education, University of Amsterdam, Room G3.13, Nieuwe Prinsengracht 130, Amsterdam 1018 VZ, The Netherlands. a.c.huizink@uva.nl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Abnormalities, Drug-Induced
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epidemiology,
etiology* Adult Alcohol Drinking / adverse effects* Animals Cannabis / adverse effects* Female Humans Male Maternal Exposure / adverse effects* Paternal Exposure / adverse effects* Pregnancy Prenatal Exposure Delayed Effects / chemically induced*, epidemiology Research Design Risk Factors Smoking / adverse effects* Young Adult |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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