| Moderate treadmill exercise prevents oxidative stress-induced anxiety-like behavior in rats. | |
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MedLine Citation:
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PMID: 20064565 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Recent work has suggested correlation of oxidative stress with anxiety-like behavior. There also is evidence for anxiolytic effects of physical exercise. However, a direct role of oxidative stress in anxiety is not clear and a protective role of physical exercise in oxidative stress-mediated anxiety has never been addressed. In this study, we have utilized rats to test direct involvement of oxidative stress with anxiety-like behavior and have identified oxidative stress mechanisms likely involved in anxiolytic effects of physical exercise. Intraperitoneal injections at non-toxic dose of l-buthionine-(S,R)-sulfoximine (BSO), an agent that increases oxidative stress markers, increased anxiety-like behavior of rats compared to vehicle-treated control rats. Prior 2 weeks treatment with the antioxidant, tempol attenuated BSO-induced anxiety-like behavior of rats suggesting a role of oxidative stress in this phenomenon. Moreover, moderate treadmill exercise prevented BSO-induced anxiety-like behavior of rats and also prevented BSO-mediated increase in oxidative stress markers in serum, urine and brain tissue homogenates from hippocampus, amygdala and locus coeruleus. Thus increasing oxidative stress increases anxiety-like behavior of rats. Moreover, antioxidant or treadmill exercise training both reduce oxidative stress in the rat brain regions implicated in anxiety response and prevent anxiety-like behavior of rats. |
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Authors:
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Samina Salim; Nada Sarraj; Manish Taneja; Kaustuv Saha; Maria Victoria Tejada-Simon; Gaurav Chugh |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-01-12 |
Journal Detail:
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Title: Behavioural brain research Volume: 208 ISSN: 1872-7549 ISO Abbreviation: Behav. Brain Res. Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-03-02 Completed Date: 2010-05-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8004872 Medline TA: Behav Brain Res Country: Netherlands |
Other Details:
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Languages: eng Pagination: 545-52 Citation Subset: IM |
Copyright Information:
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Published by Elsevier B.V. |
Affiliation:
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Department of Pharmacological and Pharmaceutical Sciences, University of Houston, Houston, TX 77204, USA. ssalim@uh.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adaptation, Ocular
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drug effects,
physiology Analysis of Variance Animals Anxiety / etiology*, pathology, prevention & control* Brain / metabolism Buthionine Sulfoximine / pharmacology Cyclic N-Oxides / pharmacology Dinoprost / analogs & derivatives, metabolism Disease Models, Animal Drug Administration Schedule Enzyme Inhibitors / pharmacology Exercise Test / methods* Exploratory Behavior / drug effects, physiology Glutathione / metabolism Male Malondialdehyde / metabolism Neuroprotective Agents / pharmacology Oxidative Stress* Physical Conditioning, Animal Radioimmunoassay / methods Rats Rats, Sprague-Dawley Spin Labels Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Cyclic N-Oxides; 0/Enzyme Inhibitors; 0/Neuroprotective Agents; 0/Spin Labels; 2226-96-2/tempol; 27415-26-5/8-epi-prostaglandin F2alpha; 5072-26-4/Buthionine Sulfoximine; 542-78-9/Malondialdehyde; 551-11-1/Dinoprost; 70-18-8/Glutathione |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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