Document Detail

Moderate intensity of regular exercise improves cardiac SR Ca2+ uptake activity in ovariectomized rats.
MedLine Citation:
PMID:  19679745     Owner:  NLM     Status:  MEDLINE    
The impact of regular exercise in protecting cardiac deteriorating results of female sex hormone deprivation was evaluated by measuring changes in intracellular Ca2+ removal activity of sarcoplasmic reticulum (SR) in ovariectomized rats following 9-wk treadmill running exercise at moderate intensity. Despite induction of cardiac hypertrophy in exercised groups of both sham-operated and ovariectomized rats, exercise training had no effect on SR Ca2+ uptake and SR Ca(2+)-ATPase (SERCA) in hormone intact rat heart. However, exercise training normalized the suppressed maximum SR Ca2+ uptake and SERCA activity in ovariectomized rat heart. While exercise training normalized the leftward shift in pCa (-log[Ca2+])-SR Ca2+ uptake relation in ovariectomized rats, no effect was detected in exercised sham-operated rats. Similar phenomena were also observed on SERCA and on phospholamban (PLB) phosphorylation levels; exercise training in ovariectomized rats enhanced SERCA expression to reach the level as that in sham-operated rats, in which there were no differences in SERCA and phospho-PLB levels between sedentary and exercised groups. In addition, the reduction in phospho-Thr(17) PLB in myocardium of ovariectomized rats was abolished by exercise training. These results showed that regular exercise maintains the molecular activation of cardiac SR Ca2+ uptake under normal physiological conditions and is able to induce a protective impact on cardiac SR Ca2+ uptake in ovarian sex hormone-deprived status.
Tepmanas Bupha-Intr; Jitanan Laosiripisan; Jonggonnee Wattanapermpool
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-08-13
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  107     ISSN:  1522-1601     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-10-16     Completed Date:  2009-12-24     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1105-12     Citation Subset:  IM    
Department of Physiology, Faculty of Science, Mahidol Univ., Rama 6 Road, Bangkok 10400, Thailand.
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MeSH Terms
Biological Transport
Calcium / metabolism*
Calcium-Binding Proteins / metabolism
Carrier Proteins / metabolism
Heart Ventricles / enzymology
Myocardium / enzymology*
Physical Exertion*
Rats, Sprague-Dawley
Sarcoplasmic Reticulum / enzymology*
Sarcoplasmic Reticulum Calcium-Transporting ATPases / metabolism*
Reg. No./Substance:
0/Calcium-Binding Proteins; 0/Carrier Proteins; 0/phospholamban; 118901-35-2/calsequestrin protein, rat; 56-45-1/Serine; 72-19-5/Threonine; 7440-70-2/Calcium; EC Reticulum Calcium-Transporting ATPases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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