| Moderate hypoxia suppresses exercise-induced procoagulant changes. | |
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MedLine Citation:
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PMID: 15086419 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hypoxia has been implicated as a stimulant of coagulation. As exertion is known to affect haemostasis, we sought to control for this by using a standardized protocol. Subjects were exercised both at room air and at 12% oxygen. Exercise produced an increase in procoagulant factors, which was reduced with hypoxic exercise. Room air exercise increased fibrinolytic markers. Hypoxic exercise did not affect the increase in tissue plasminogen activator, but decreased the increase in plasminogen activator inhibitor-1 expression. Thus, it appears that hypoxia may exert an antithrombotic effect by both damping exercise-induced procoagulant changes and stimulating fibrinolysis. |
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Authors:
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Thomas G DeLoughery; Deborah G Robertson; Cristina A Smith; David Sauer |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: British journal of haematology Volume: 125 ISSN: 0007-1048 ISO Abbreviation: Br. J. Haematol. Publication Date: 2004 May |
Date Detail:
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Created Date: 2004-04-16 Completed Date: 2004-06-04 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0372544 Medline TA: Br J Haematol Country: England |
Other Details:
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Languages: eng Pagination: 369-72 Citation Subset: IM |
Affiliation:
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Division of Hematology/Medical Oncology, Department of Medicine, Oregan Health and Science Univerity, Portland, OR 97239-3098, USA. delought@ohsu.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Altitude Anoxia / blood* Blood Coagulation / physiology* Blood Coagulation Factors / metabolism Exercise / physiology* Exercise Test / methods Fibrinolysis / physiology Humans |
| Grant Support | |
ID/Acronym/Agency:
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M01 RR000334/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Blood Coagulation Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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