Document Detail


Moderate hypoxia suppresses exercise-induced procoagulant changes.
MedLine Citation:
PMID:  15086419     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Hypoxia has been implicated as a stimulant of coagulation. As exertion is known to affect haemostasis, we sought to control for this by using a standardized protocol. Subjects were exercised both at room air and at 12% oxygen. Exercise produced an increase in procoagulant factors, which was reduced with hypoxic exercise. Room air exercise increased fibrinolytic markers. Hypoxic exercise did not affect the increase in tissue plasminogen activator, but decreased the increase in plasminogen activator inhibitor-1 expression. Thus, it appears that hypoxia may exert an antithrombotic effect by both damping exercise-induced procoagulant changes and stimulating fibrinolysis.
Authors:
Thomas G DeLoughery; Deborah G Robertson; Cristina A Smith; David Sauer
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  British journal of haematology     Volume:  125     ISSN:  0007-1048     ISO Abbreviation:  Br. J. Haematol.     Publication Date:  2004 May 
Date Detail:
Created Date:  2004-04-16     Completed Date:  2004-06-04     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0372544     Medline TA:  Br J Haematol     Country:  England    
Other Details:
Languages:  eng     Pagination:  369-72     Citation Subset:  IM    
Affiliation:
Division of Hematology/Medical Oncology, Department of Medicine, Oregan Health and Science Univerity, Portland, OR 97239-3098, USA. delought@ohsu.edu
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MeSH Terms
Descriptor/Qualifier:
Altitude
Anoxia / blood*
Blood Coagulation / physiology*
Blood Coagulation Factors / metabolism
Exercise / physiology*
Exercise Test / methods
Fibrinolysis / physiology
Humans
Grant Support
ID/Acronym/Agency:
M01 RR000334/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Blood Coagulation Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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