| Moderate hypothermia induces a preferential increase in pancreatic islet blood flow in anesthetized rats. | |
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MedLine Citation:
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PMID: 17626132 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of the study was to characterize the effects of induced moderate hypothermia on splanchnic blood flow, with particular reference to that of the pancreas and the islets of Langerhans. We also investigated how interference with the autonomic nervous system at different levels influenced the blood perfusion during hypothermia. For this purpose, hypothermia (body temperature of 28 degrees C) was induced by external cooling, whereas normothermic (37.5 degrees C) anesthetized Sprague-Dawley rats were used as controls. Some rats were pretreated with either propranolol, yohimbine, atropine, hexamethonium, or a bilateral abdominal vagotomy. Our findings suggest that moderate hypothermia elicits complex, organ-specific circulatory changes, with increased perfusion noted in the pylorus, as well as the whole pancreas and the pancreatic islets. The pancreatic islets maintain their high blood perfusion through mechanisms involving both sympathetic and parasympathetic mediators, whereas the increased pyloric blood flow is mediated through parasympathetic mechanisms. Renal blood flow was decreased, and this can be prevented by ganglionic blockade and is also influenced by beta-adrenoceptors. |
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Authors:
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Michael Hultström; Leif Jansson; Birgitta Bodin; Orjan Källskog |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-07-11 |
Journal Detail:
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Title: American journal of physiology. Regulatory, integrative and comparative physiology Volume: 293 ISSN: 0363-6119 ISO Abbreviation: Am. J. Physiol. Regul. Integr. Comp. Physiol. Publication Date: 2007 Sep |
Date Detail:
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Created Date: 2007-08-31 Completed Date: 2007-10-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100901230 Medline TA: Am J Physiol Regul Integr Comp Physiol Country: United States |
Other Details:
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Languages: eng Pagination: R1438-43 Citation Subset: IM |
Affiliation:
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Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden. michael.hultstrom@med.uib.no |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenal Glands
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blood supply Adrenergic alpha-Antagonists / pharmacology Adrenergic beta-Antagonists / pharmacology Anesthesia Animals Blood Glucose / metabolism Hypothermia, Induced* Insulin / blood Intestines / blood supply Islets of Langerhans / blood supply* Male Muscarinic Antagonists / pharmacology Nicotinic Antagonists / pharmacology Pylorus / blood supply Rats Rats, Sprague-Dawley Regional Blood Flow / physiology Renal Circulation / physiology Splanchnic Circulation / physiology Sympathetic Nervous System / physiology Vagotomy |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic alpha-Antagonists; 0/Adrenergic beta-Antagonists; 0/Blood Glucose; 0/Muscarinic Antagonists; 0/Nicotinic Antagonists; 11061-68-0/Insulin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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