Document Detail

Moderate hypothermia induces a preferential increase in pancreatic islet blood flow in anesthetized rats.
MedLine Citation:
PMID:  17626132     Owner:  NLM     Status:  MEDLINE    
The aim of the study was to characterize the effects of induced moderate hypothermia on splanchnic blood flow, with particular reference to that of the pancreas and the islets of Langerhans. We also investigated how interference with the autonomic nervous system at different levels influenced the blood perfusion during hypothermia. For this purpose, hypothermia (body temperature of 28 degrees C) was induced by external cooling, whereas normothermic (37.5 degrees C) anesthetized Sprague-Dawley rats were used as controls. Some rats were pretreated with either propranolol, yohimbine, atropine, hexamethonium, or a bilateral abdominal vagotomy. Our findings suggest that moderate hypothermia elicits complex, organ-specific circulatory changes, with increased perfusion noted in the pylorus, as well as the whole pancreas and the pancreatic islets. The pancreatic islets maintain their high blood perfusion through mechanisms involving both sympathetic and parasympathetic mediators, whereas the increased pyloric blood flow is mediated through parasympathetic mechanisms. Renal blood flow was decreased, and this can be prevented by ganglionic blockade and is also influenced by beta-adrenoceptors.
Michael Hultström; Leif Jansson; Birgitta Bodin; Orjan Källskog
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-07-11
Journal Detail:
Title:  American journal of physiology. Regulatory, integrative and comparative physiology     Volume:  293     ISSN:  0363-6119     ISO Abbreviation:  Am. J. Physiol. Regul. Integr. Comp. Physiol.     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-08-31     Completed Date:  2007-10-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100901230     Medline TA:  Am J Physiol Regul Integr Comp Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  R1438-43     Citation Subset:  IM    
Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden.
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MeSH Terms
Adrenal Glands / blood supply
Adrenergic alpha-Antagonists / pharmacology
Adrenergic beta-Antagonists / pharmacology
Blood Glucose / metabolism
Hypothermia, Induced*
Insulin / blood
Intestines / blood supply
Islets of Langerhans / blood supply*
Muscarinic Antagonists / pharmacology
Nicotinic Antagonists / pharmacology
Pylorus / blood supply
Rats, Sprague-Dawley
Regional Blood Flow / physiology
Renal Circulation / physiology
Splanchnic Circulation / physiology
Sympathetic Nervous System / physiology
Reg. No./Substance:
0/Adrenergic alpha-Antagonists; 0/Adrenergic beta-Antagonists; 0/Blood Glucose; 0/Muscarinic Antagonists; 0/Nicotinic Antagonists; 11061-68-0/Insulin

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