Document Detail


Moderate exercise, postprandial lipaemia and triacylglycerol clearance.
MedLine Citation:
PMID:  11264646     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Moderate intensity exercise reduces postprandial triacylglycerol (TG) concentrations. We tested whether this reflects increased TG clearance. Eight normotriglyceridaemic men, aged 48.3 +/- 7.3 years (mean +/- SD), performed two oral fat tolerance tests (blood samples taken in the fasted state and for six hours after a high-fat meal containing 1.00 g fat, 0.97 g carbohydrate, 58 kJ energy kg-1 fat-free body mass) and two intravenous fat tolerance tests (blood samples in the fasted state and after a bolus injection of Intralipid, 0.1 g fat kg-1 body mass). The afternoon before one oral and one intravenous test, subjects walked briskly for 90 min; no exercise was performed before the control tests. Prior exercise reduced fasting TG concentration similarly in the oral (16 +/- 7 %) (mean +/- SEM) and intravenous (18 +/- 7 %) tests, and reduced postprandial TG concentrations in the oral test by 18 +/- 6 % (all P < 0.05). However, prior exercise did not increase Intralipid clearance (disappearance curve slopes: control, 4.69 +/- 0.49 % min-1; exercise, 4.85 +/- 0.40 % min-1). These data suggest that mechanisms other than increased TG clearance mediate the lower postprandial TG concentrations seen after moderate exercise.
Authors:
J M Gill; G P Mees; K N Frayn; A E Hardman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of clinical investigation     Volume:  31     ISSN:  0014-2972     ISO Abbreviation:  Eur. J. Clin. Invest.     Publication Date:  2001 Mar 
Date Detail:
Created Date:  2001-03-26     Completed Date:  2001-06-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0245331     Medline TA:  Eur J Clin Invest     Country:  England    
Other Details:
Languages:  eng     Pagination:  201-7     Citation Subset:  IM    
Affiliation:
Loughborough University, Loughborough, UK. j.gill@clinmed.gla.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Dietary Fats / administration & dosage
Exercise / physiology*
Exercise Test
Fasting
Fat Emulsions, Intravenous / administration & dosage
Fatty Acids, Nonesterified / blood
Humans
Injections, Intravenous
Lipids / blood
Lipoproteins / blood*
Male
Middle Aged
Postprandial Period / physiology*
Triglycerides / blood*,  pharmacokinetics
Walking / physiology
Chemical
Reg. No./Substance:
0/Dietary Fats; 0/Fat Emulsions, Intravenous; 0/Fatty Acids, Nonesterified; 0/Lipids; 0/Lipoproteins; 0/Triglycerides

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