Document Detail


Moderate exercise increases the metabolism and immune function of lymphocytes in rats.
MedLine Citation:
PMID:  23212119     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Exercise modulates both glucose and glutamine metabolism which influences lymphocyte function. We investigated the influence of chronic moderate exercise on glucose and glutamine metabolism in lymphocytes, the associated influence on proliferation, and cytokine and immunoglobulin production. Male Wistar rats (8 weeks old) were placed in an exercise training group (N = 15, 1 h day(-1) at 60 % VO(2max), 5 days week(-1)) for 8 weeks of exercise, or a sedentary control group. Twenty-four hours following the final training session, lymphocytes were separated, and the incorporation of [U-14C]-glucose, [U-14C]-glutamine, and [2-14C]-thymidine from the supernatant was measured. The activity of glucose-6-phosphate dehydrogenase, hexokinase, and glutaminase was measured. Lymphocytes were stimulated with ConA and LPS and incubated with the Mycobacterium bovis bacille Calmette-Guerin (BCG) vaccine and plasma IgG and IgE were measured. Glutamine metabolism increased in both T and B lymphocytes in the trained group. In the trained group, proliferative capacity increased T lymphocytes under ConA stimulation, and increased B lymphocytes with LPS. There was a significant increase in IL-2 production and decrease in IL-4 in the trained group compared with sedentary controls. IL-2R and TNFR increased in trained rats while IL-4R decreased and were more pronounced in T lymphocytes compared with B lymphocytes. In both lymphocyte subsets, exercise training significantly increased the expression of CD54+ and CD30+ cell markers. Exercise training increased plasma IgG compared with the sedentary group. In conclusion, moderate exercise training improves immune function and metabolism in T and B lymphocytes, reflecting an increased ability to respond to immune challenges.
Authors:
Francisco Navarro; Aline Villa Nova Bacurau; Guilherme Borges Pereira; Ronaldo Carvalho Araújo; Sandro Soares Almeida; Milton Rocha Moraes; Marco Carlos Uchida; Luis Fernando Bicudo Pereira Costa Rosa; James Navalta; Jonato Prestes; Reury Frank Pereira Bacurau
Related Documents :
9377909 - Ventilatory support during exercise in patients with pulmonary tuberculosis sequelae.
11094009 - Respiratory efficacy of subglottic low-frequency, subglottic combined-frequency, and su...
8370289 - Perfluorocarbon-associated gas exchange (partial liquid ventilation) in respiratory dis...
12183509 - Alterations in regional ventilation, perfusion, and shunt after smoke inhalation measur...
8282639 - Effect of ventilation frequency and tidal volume on pleural space thickness in rabbits.
1592909 - The functional significance of ventilation frequency, and its relationship to oxygen de...
16088059 - Application of threshold-based acceleration change index (taci) in heart rate variabili...
3146399 - The effects of nitroglycerin on regional myocardial contractile dysfunction produced by...
1459749 - Physiological changes in male competitive cyclists after two weeks of intensified train...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-2
Journal Detail:
Title:  European journal of applied physiology     Volume:  -     ISSN:  1439-6327     ISO Abbreviation:  Eur. J. Appl. Physiol.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100954790     Medline TA:  Eur J Appl Physiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Physical Education, Federal University of Maranhao, Av. dos Portugueses, S/N, São Luís, MA, CEP 65085-580, Brazil.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Single-site N-N bond cleavage by Mo(iv): possible mechanisms of hydrazido(1-) to nitrido conversion.
Next Document:  Synthesis and structural transformations of colloidal 2D layered metal chalcogenide nanocrystals.