| Moderate exercise improves leucocyte function and decreases inflammation in diabetes. | |
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MedLine Citation:
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PMID: 20846161 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The genesis and progression of diabetes occur due in part to an uncontrolled inflammation profile with insulin resistance, increased serum levels of free fatty acids (FFA), proinflammatory cytokines and leucocyte dysfunction. In this study, an investigation was made of the effect of a 3-week moderate exercise regimen on a treadmill (60% of VO₂(max) , 30 min/day, 6 days a week) on inflammatory markers and leucocyte functions in diabetic rats. The exercise decreased serum levels of tumour necrosis factor (TNF)-α (6%), cytokine-induced neutrophil chemotactic factor 2 alpha/beta (CINC-2α/β) (9%), interleukin (IL)-1β (34%), IL-6 (86%), C-reactive protein (CRP) (41%) and FFA (40%) in diabetic rats when compared with sedentary diabetic animals. Exercise also attenuated the increased responsiveness of leucocytes from diabetics when compared to controls, diminishing the reactive oxygen species (ROS) release by neutrophils (21%) and macrophages (28%). Exercise did not change neutrophil migration and the proportion of neutrophils and macrophages in necrosis (loss of plasma membrane integrity) and apoptosis (DNA fragmentation). Serum activities of creatine kinase (CK) and lactate dehydrogenase (LDH) were not modified in the conditions studied. Therefore, physical training did not alter the integrity of muscle cells. We conclude that moderate physical exercise has marked anti-inflammatory effects on diabetic rats. This may be an efficient strategy to protect diabetics against microorganism infection, insulin resistance and vascular complications. |
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Authors:
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M F Belotto; J Magdalon; H G Rodrigues; M A R Vinolo; R Curi; T C Pithon-Curi; E Hatanaka |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-09-15 |
Journal Detail:
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Title: Clinical and experimental immunology Volume: 162 ISSN: 1365-2249 ISO Abbreviation: Clin. Exp. Immunol. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-11-02 Completed Date: 2011-01-10 Revised Date: 2011-11-01 |
Medline Journal Info:
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Nlm Unique ID: 0057202 Medline TA: Clin Exp Immunol Country: England |
Other Details:
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Languages: eng Pagination: 237-43 Citation Subset: IM |
Copyright Information:
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© 2010 The Authors. Clinical and Experimental Immunology © 2010 British Society for Immunology. |
Affiliation:
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Cruzeiro do Sul University, Brazil. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Apoptosis / immunology C-Reactive Protein / metabolism Chemokines, CXC / blood Creatine Kinase / blood Cytokines / blood Diabetes Mellitus, Experimental / blood, immunology*, therapy Diabetes Mellitus, Type 1 / blood, immunology, therapy Fatty Acids, Nonesterified / blood Inflammation / blood, immunology Interleukins / blood L-Lactate Dehydrogenase / blood Leukocytes / immunology*, metabolism Macrophages, Peritoneal / cytology, drug effects, metabolism, pathology Male Necrosis / immunology, pathology Neutrophils / cytology, drug effects, metabolism, pathology Peritoneal Cavity / cytology Physical Conditioning, Animal / physiology* Rats Rats, Wistar Reactive Oxygen Species / metabolism Tetradecanoylphorbol Acetate / pharmacology Tumor Necrosis Factor-alpha / blood |
| Chemical | |
Reg. No./Substance:
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0/Chemokines, CXC; 0/Cytokines; 0/Fatty Acids, Nonesterified; 0/Gm1960 protein, rat; 0/Interleukins; 0/Reactive Oxygen Species; 0/Tumor Necrosis Factor-alpha; 16561-29-8/Tetradecanoylphorbol Acetate; 9007-41-4/C-Reactive Protein; EC 1.1.1.27/L-Lactate Dehydrogenase; EC 2.7.3.2/Creatine Kinase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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