Document Detail

Moderate exercise improves depression parameters in treatment-resistant patients with major depressive disorder.
MedLine Citation:
PMID:  21377690     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Treatment-resistant major depressive disorder (MDD) is a complex condition, with very low remission rates. Physical exercise has been used, with some encouraging results, as an alternative therapy in other depressive disorders. This study assessed the impact on depression and functioning parameters of a moderate intensity exercise program, as an adjuvant to pharmacotherapy, in treatment-resistant MDD patients.
METHODS: 150 individuals with treatment-resistant MDD, defined as taking combined therapy in doses considered adequate for 9-15 months, without showing clinical remission, were initially screened. 33 were randomized to one of two groups: usual pharmacotherapy (N = 11) and usual pharmacotherapy plus aerobic exercise (N = 22). The exercise program consisted of home-based 30-45 min/day walks, 5 days/week, for 12 weeks, being 1 walk per week supervised.
RESULTS: The exercise group showed improvement of all depression and functioning parameters, as indicated by lower HAMD17, BDI and CGI-S and higher GAF (p < 0.05) at last observation compared both to baseline values and to control group. At the end of the study none of the participants in the control group showed response or remission, whilst in the exercise group 21% of participants showed response and 26% remission, although these differences were not statistically significant.
CONCLUSION: A 12 week, home-based exercise program of 30-45 min/day walks, 5 days/week, improved depression and functioning parameters in treatment-resistant MDD patients, and contributed to remission of 26% of these patients. Moderate intensity exercise may be a helpful and effective adjuvant therapy for treatment-resistant MDD.
Jorge Mota-Pereira; Jorge Silverio; Serafim Carvalho; Jose Carlos Ribeiro; Daniela Fonte; Joaquim Ramos
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2011-03-05
Journal Detail:
Title:  Journal of psychiatric research     Volume:  45     ISSN:  1879-1379     ISO Abbreviation:  J Psychiatr Res     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-07-25     Completed Date:  2011-11-29     Revised Date:  2011-12-13    
Medline Journal Info:
Nlm Unique ID:  0376331     Medline TA:  J Psychiatr Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  1005-11     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Ltd. All rights reserved.
Porto Psychiatric Department, Hospital Magalhaes Lemos, Porto, Portugal; School of Psychology, University of Minho, Portugal.
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MeSH Terms
Analysis of Variance
Antidepressive Agents / therapeutic use
Blood Pressure / physiology
Body Mass Index
Depressive Disorder, Major / drug therapy,  physiopathology*,  rehabilitation*
Double-Blind Method
Exercise Therapy / methods*
Follow-Up Studies
Heart Rate / physiology
Middle Aged
Prospective Studies
Psychiatric Status Rating Scales
Time Factors
Treatment Outcome
Reg. No./Substance:
0/Antidepressive Agents
Comment In:
J Psychiatr Res. 2011 Dec;45(12):1657-9   [PMID:  21908006 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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