| Moderate-dose intravenous immunoglobulin treatment of Job's syndrome. Case report. | |
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MedLine Citation:
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PMID: 11084845 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Job's syndrome (or hyperimmunoglobulinemia E syndrome) is a rare genetic disease characterized by skin eczema, pyogenic "cold" abscesses, sinopulmonary recidivous infections and high IgE plasma concentrations. Job's syndrome treatment is not satisfactory and cases studied are still limited. To describe the effects of IVIG therapy in a 37-year-old woman with hyper IgE syndrome and pneumonia. We measured IgE serum by immuno-fluorometric test and neutrophil chemotaxis by migration in a Boyden chamber before and after IVIG therapy. A moderate dose of IVIG resolved the clinical-radiological signs of the S. aureus bronchopneumonia and improved cytologic and biohumoral parameters. Intravenous immunoglobulins represent a useful treatment for acute pneumonia in Job's syndrome. |
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Authors:
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F Bilora; F Petrobelli; V Boccioletti; F Pomerri |
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Publication Detail:
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Type: Case Reports; Comparative Study; Journal Article |
Journal Detail:
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Title: Minerva medica Volume: 91 ISSN: 0026-4806 ISO Abbreviation: Minerva Med. Publication Date: 2000 May-Jun |
Date Detail:
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Created Date: 2000-12-01 Completed Date: 2000-12-01 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0400732 Medline TA: Minerva Med Country: ITALY |
Other Details:
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Languages: eng Pagination: 113-6 Citation Subset: IM |
Affiliation:
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Department of Surgery and Medicine, Padua University. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Chemotaxis, Leukocyte Female Fluorometry Humans Immunoglobulin E / blood Immunoglobulins, Intravenous / administration & dosage* Job's Syndrome / complications, immunology, therapy* Neutrophils Pneumonia, Staphylococcal / diagnosis, etiology, therapy Radiography, Thoracic |
| Chemical | |
Reg. No./Substance:
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0/Immunoglobulins, Intravenous; 37341-29-0/Immunoglobulin E |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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