| Moderate dietary intake of myristic and alpha-linolenic acids increases lecithin-cholesterol acyltransferase activity in humans. | |
| | |
MedLine Citation:
|
PMID: 17564735 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Cholesterol removal from tissues into HDL depends on the activity of lecithin-cholesterol acyltransferase (LCAT; E.C. 2.3.1.43) that is associated with lower cardiovascular diseases risk. HDL cholesterol concentration and LCAT activity can be modulated by dietary fatty acids. Original data with substrate models have shown a positive effect of myristic acid (MA) on the esterification rate of cholesterol. The purpose of this study was to examine the effect of moderate intakes of MA associated with recommended intake of alpha-linolenic acid (ALA) on LCAT activity in humans. Two experimental diets were tested for 3 months each. Diet 1-MA 1.2% of total energy (TE) and ALA 0.9% TE, diet 2-MA 1.8% and ALA 0.9% TE; a control diet (MA 1.2% and ALA 0.4% TE) was given 3 months before diet 1 and diet 2. The endogenous activity of LCAT was determined at completion of each diet. Compared with the control diet (13.2 +/- 3.1 micromol CE/(L x h)), LCAT activity increased significantly (P < 0.001) with diet 1 (24.2 +/- 3.6 micromol CE/(L x h)) and diet 2 (33.3 +/- 7.4 micromol CE/(L x h)); the increase observed with diet 2 was significantly (P < 0.001) greater than that due to diet 1. These results suggest that ALA (from rapeseed oil, mainly in sn-2 position) and MA (from dairy fat, mainly in sn-2 position) favor LCAT activity, by respective increases of 83 and 38%. When they are supplied together, a complementary effect was observed (average increase of 152%). Moreover, these observations were associated with a decrease of the ratio of total to HDL-cholesterol. In conclusion, our results suggest that moderate supply of MA (1.8% TE) associated with the recommended intake of ALA (0.9% TE) contributes to improve LCAT activity. |
| | |
Authors:
|
Carole Vaysse-Boué; Henry Dabadie; Evelyne Peuchant; Pascale Le Ruyet; François Mendy; Henry Gin; Nicole Combe |
Related Documents
:
|
3630775 - Alpha-lecithin:cholesterol acyltransferase deficiency. lack of both phospholipase a2 an... 9932095 - Effect of a supplementary dietary evening primrose oil mixture on hoof growth, hoof gro... 9627145 - Effect of 20 days' bed rest on the reverse cholesterol transport system in healthy youn... 2783205 - Relationship between serum cholesteryl ester composition, dietary habits and coronary r... 7985625 - Recovery of initial body weight and composition after long-term massive overfeeding in ... 1437975 - Valine deficiency. 2. the effect of feeding a valine-deficient diet during the starter ... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-06-13 |
Journal Detail:
|
Title: Lipids Volume: 42 ISSN: 0024-4201 ISO Abbreviation: Lipids Publication Date: 2007 Aug |
Date Detail:
|
Created Date: 2007-07-24 Completed Date: 2007-12-12 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0060450 Medline TA: Lipids Country: United States |
Other Details:
|
Languages: eng Pagination: 717-22 Citation Subset: IM |
Affiliation:
|
ITERG, Département de Nutrition, c/o Université Bordeaux 1, Avenue des Facultés, 33405, Talence Cedex, France. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Aged, 80 and over Dietary Fats / administration & dosage, pharmacology Humans Lipids / blood Lipoproteins / blood Male Middle Aged Myristic Acid / administration & dosage*, pharmacology Phosphatidylcholine-Sterol O-Acyltransferase / blood, metabolism* alpha-Linolenic Acid / administration & dosage*, pharmacology |
| Chemical | |
Reg. No./Substance:
|
0/Dietary Fats; 0/Lipids; 0/Lipoproteins; 463-40-1/alpha-Linolenic Acid; 544-63-8/Myristic Acid; EC 2.3.1.43/Phosphatidylcholine-Sterol O-Acyltransferase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: False activation in the brain ventricles related to task-correlated breathing in fMRI speech and mot...
Next Document: Dynamic instability during stair descent in isolated PCL-deficient knees: what affects abnormal post...