| Moderate daily exercise activates metabolic flexibility to prevent prenatally induced obesity. | |
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MedLine Citation:
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PMID: 18772230 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Obesity and its associated comorbidities are of major worldwide concern. It is now recognized that there are a number of metabolically distinct pathways of obesity development. The present paper investigates the effect of moderate daily exercise on the underlying mechanisms of one such pathway to obesity, through interrogation of metabolic flexibility. Pregnant Wistar rats were either fed chow ad libitum or undernourished throughout pregnancy, generating control or intrauterine growth restricted (IUGR) offspring, respectively. At 250 d of age, dual-emission x-ray absorptiometry scans and plasma analyses showed that moderate daily exercise, in the form of a measured amount of wheel running (56 m/d), prevented the development of obesity consistently observed in nonexercised IUGR offspring. Increased plasma C-peptide and hepatic atypical protein kinase Czeta levels explained increased glucose uptake and increased hepatic glycogen storage in IUGR offspring. Importantly, whereas circulating levels of retinol binding protein 4 were elevated in obese, nonexercised IUGR offspring, indicative of glucose sparing without exercise, retinol binding protein 4 levels were normalized in the exercised IUGR group. These data suggest that IUGR offspring have increased flexibility of energy storage and use and that moderate daily exercise prevents obesity development through activation of distinct pathways of energy use. Thus, despite a predisposition to develop obesity under sedentary conditions, obesity development was prevented in IUGR offspring when exercise was available. These results emphasize the importance of tailored lifestyle changes that activate distinct pathways of metabolic flexibility for obesity prevention. |
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Authors:
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Jennifer L Miles; Korinna Huber; Nichola M Thompson; Michael Davison; Bernhard H Breier |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-09-04 |
Journal Detail:
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Title: Endocrinology Volume: 150 ISSN: 0013-7227 ISO Abbreviation: Endocrinology Publication Date: 2009 Jan |
Date Detail:
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Created Date: 2008-12-30 Completed Date: 2009-03-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375040 Medline TA: Endocrinology Country: United States |
Other Details:
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Languages: eng Pagination: 179-86 Citation Subset: AIM; IM |
Affiliation:
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Liggins Institute, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animal Feed Animals Blood Glucose / metabolism Body Composition C-Peptide / blood Diet, Reducing / veterinary Energy Intake Female Fetal Growth Retardation / epidemiology, etiology Insulin / blood Leptin / blood Lipids / blood Obesity / embryology*, prevention & control* Physical Conditioning, Animal* Pregnancy Rats Rats, Wistar Retinol-Binding Proteins, Plasma / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/C-Peptide; 0/Leptin; 0/Lipids; 0/Rbp4 protein, rat; 0/Retinol-Binding Proteins, Plasma; 11061-68-0/Insulin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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