Document Detail


Moderate altitude increases right ventricular pressure and oxygen desaturation in adolescents with surgically closed septal defect.
MedLine Citation:
PMID:  21106015     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: Abnormal right ventricular systolic pressure response (RVPR) during exercise has previously been demonstrated in patients with septal defects of the heart. Our study investigated whether moderate altitude affects RVPR and oxygen saturation during rest and exercise in patients with surgically closed septal defects.
DESIGN: Ten patients with surgically closed heart septal defects (six secundum atrial septal defects, four ventricular septal defects) were examined by cardiopulmonary exercise testing and by echocardiography at rest and during supine cycling at sea level. After 2 hours in a hypobaric chamber at 2500 m/8200 ft altitude, exercise echocardiography was repeated.
RESULTS: During sea level exercise four patients showed abnormal RVPR (>50 mm Hg). Acute hypoxic exposure led to right ventricular systolic pressure increase above 40 mm Hg in two patients. During altitude exercise seven patients showed abnormal RVPR. Average maximal right ventricular systolic pressure was 56.5 ± 12.7 mm Hg and average for the lowest oxygen saturation was 80.0 ± 5.7%. Two patients had simultaneous oxygen desaturation below 80% and right ventricular systolic pressure above 50 mm Hg.
CONCLUSIONS: Moderate altitude affects right ventricular systolic pressure and oxygen saturation in adolescents with surgically closed ventricular or atrial septal defects. Moderate altitude may induce or aggravate abnormal RVPR and oxygen desaturation during exercise in these patients.
Authors:
Thomas Möller; Henrik Brun; Per M Fredriksen; Henrik Holmstrøm; Eirik Pettersen; Erik Thaulow
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Congenital heart disease     Volume:  5     ISSN:  1747-0803     ISO Abbreviation:  Congenit Heart Dis     Publication Date:    2010 Nov-Dec
Date Detail:
Created Date:  2010-11-25     Completed Date:  2011-03-10     Revised Date:  2011-05-05    
Medline Journal Info:
Nlm Unique ID:  101256510     Medline TA:  Congenit Heart Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  556-64     Citation Subset:  IM    
Copyright Information:
© 2010 Copyright the Authors. Congenital Heart Disease © 2010 Wiley Periodicals, Inc.
Affiliation:
Pediatric Department, Vestfold Hospital Trust, Tønsberg, Norway. thomas.moller@siv.no
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Altitude*
Anoxia / metabolism*,  physiopathology*,  ultrasonography
Bicycling
Cardiac Surgical Procedures*
Echocardiography, Doppler
Exercise Test
Female
Heart Septal Defects, Atrial / surgery*
Heart Septal Defects, Ventricular / surgery*
Humans
Male
Norway
Oxygen / metabolism*
Time Factors
Treatment Outcome
Ventricular Function, Right*
Ventricular Pressure*
Young Adult
Chemical
Reg. No./Substance:
7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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