Document Detail


Moderate altitude but not additional endurance training increases markers of oxidative stress in exhaled breath condensate.
MedLine Citation:
PMID:  19363619     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Oxidative stress occurs at altitude, and physical exertion might enhance this stress. In the present study, we investigated the combined effects of exercise and moderate altitude on redox balance in ten endurance exercising biathletes, and five sedentary volunteers during a 6-week-stay at 2,800 m. As a marker for oxidative stress, hydrogen peroxide (H(2)O(2)) was analyzed by the biosensor measuring system Ecocheck, and 8-iso prostaglandin F2alpha (8-iso PGF2alpha) was determined by enzyme immunoassay in exhaled breath condensate (EBC). To determine the whole blood antioxidative capacity, we measured reduced glutathione (GSH) enzymatically using Ellman's reagent. Exercising athletes and sedentary volunteers showed increased levels of oxidative markers at moderate altitude, contrary to our expectations; there was no difference between both groups. Therefore, all subjects' data were pooled to examine the oxidative stress response exclusively due to altitude exposure. H(2)O(2) levels increased at altitude and remained elevated for 3 days after returning to sea level (p < or = 0.05). On the other hand, 8-iso PGF2alpha levels showed a tendency to increase at altitude, but declined immediately after returning to sea level (p < or = 0.001). Hypoxic exposure during the first day at altitude resulted in elevated GSH levels (p < or = 0.05), that decreased during prolonged sojourn at altitude (p < or = 0.001). In conclusion, a stay at moderate altitude for up to 6 weeks increases markers of oxidative stress in EBC independent of additional endurance training. Notably, this oxidative stress is still detectable 3 days upon return to sea level.
Authors:
Ilmar Heinicke; Annette Boehler; Thomas Rechsteiner; Anna Bogdanova; Wolfgang Jelkmann; Markus Hofer; Pablo Rawlings; Oscar F Araneda; Claus Behn; Max Gassmann; Katja Heinicke
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-04-11
Journal Detail:
Title:  European journal of applied physiology     Volume:  106     ISSN:  1439-6327     ISO Abbreviation:  Eur. J. Appl. Physiol.     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-06-09     Completed Date:  2009-08-19     Revised Date:  2010-01-21    
Medline Journal Info:
Nlm Unique ID:  100954790     Medline TA:  Eur J Appl Physiol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  599-604     Citation Subset:  IM    
Affiliation:
Vetsuisse Faculty and Zurich Center for Integrative Human Physiology, Institute of Veterinary Physiology, University of Zurich, Zurich, Switzerland.
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MeSH Terms
Descriptor/Qualifier:
Altitude*
Breath Tests*
Exhalation / physiology*
Female
Humans
Male
Oxidative Stress / physiology*
Physical Endurance / physiology*
Physical Exertion / physiology*
Physical Fitness / physiology*
Reactive Oxygen Species / analysis*
Young Adult
Chemical
Reg. No./Substance:
0/Reactive Oxygen Species
Comments/Corrections
Comment In:
Eur J Appl Physiol. 2010 Jan;108(1):213   [PMID:  19760254 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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