Document Detail

Moderate alcohol use and mortality from ischaemic heart disease: a prospective study in older Chinese people.
Jump to Full Text
MedLine Citation:
PMID:  18523644     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Moderate alcohol use is generally associated with lower ischaemic heart disease (IHD) mortality but it is difficult to ascertain whether this is due to attributes of moderate alcohol users or the properties of alcohol itself. Evidence from populations with different patterns of alcohol use and IHD can provide crucial evidence. We assessed the association of moderate alcohol use with IHD mortality in older Chinese people from Hong Kong.
METHODOLOGY: We used Cox regression to determine whether moderate alcohol use was associated with IHD mortality in a prospective, population-based cohort study of all 56,167 attendees, aged 65 years or over, from July 1998 to December 2000 at all 18 Elderly Health Centers operated by the Department of Health in Hong Kong.
PRINCIPAL FINDINGS: After a median follow-up of 4.2 years, there were 406 (188 in men, 218 in women) deaths from IHD in 54,090 subjects (96.3% successful follow-up). Moderate alcohol use in men was not associated with IHD mortality adjusted only for age [Hazard Ratio, HR 1.01 (95% CI 0.55 to 1.84) compared with never drinkers] or additionally adjusted for socio-economic status and lifestyle. Almost all women were occasional drinkers and their current alcohol use was not significantly associated with IHD mortality [HR 0.88, (95% CI 0.51 to 1.53)].
CONCLUSIONS: Moderate alcohol use had no effect on IHD mortality in older Chinese men. Lack of replication of the usual protective effect of moderate alcohol use in a setting with a different pattern of alcohol use and IHD could be due to chance or could suggest that the protective effect of alcohol on IHD does not extend to all populations.
C Mary Schooling; Wenjie Sun; Sun Wenjie; Sai Yin Ho; Wai Man Chan; May Ked Tham; Kin Sang Ho; Gabriel M Leung; Tai Hing Lam
Related Documents :
19886584 - Alcohol-related motor vehicle accident fatality: wisconsin rural-urban trends and obser...
22276954 - Sex work involvement among women with long-term opioid injection drug dependence who en...
1530134 - Antecedents and covariates of high alcohol consumption in young men.
18715274 - Biphasic effects of moderate drinking on prolactin during lactation.
3431474 - Defining menopausal status: the impact of longitudinal data.
3276594 - Physical and psychological problems associated with exposure to diethylstilbestrol (des).
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-06-04
Journal Detail:
Title:  PloS one     Volume:  3     ISSN:  1932-6203     ISO Abbreviation:  PLoS ONE     Publication Date:  2008  
Date Detail:
Created Date:  2008-06-04     Completed Date:  2008-08-20     Revised Date:  2013-06-05    
Medline Journal Info:
Nlm Unique ID:  101285081     Medline TA:  PLoS One     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e2370     Citation Subset:  IM    
Department of Community Medicine and School of Public Health, The University of Hong Kong, Hong Kong SAR, China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Alcohol Drinking*
Cohort Studies
Myocardial Ischemia / physiopathology*
Proportional Hazards Models
Prospective Studies
Erratum In:
PLoS ONE. 2008;3(6). doi: 10.1371/annotation/d27238c8-7f54-4bbb-afa4-b99443f1b9f0
Note: Wenjie, Sun [corrected to Sun, Wenjie]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Full Text
Journal Information
Journal ID (nlm-ta): PLoS ONE
Journal ID (publisher-id): plos
Journal ID (pmc): plosone
ISSN: 1932-6203
Publisher: Public Library of Science, San Francisco, USA
Article Information
Download PDF
Schooling et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Received Day: 17 Month: 1 Year: 2008
Accepted Day: 1 Month: 5 Year: 2008
collection publication date: Year: 2008
Electronic publication date: Day: 4 Month: 6 Year: 2008
Volume: 3 Issue: 6
E-location ID: e2370
ID: 2396290
PubMed Id: 18523644
Publisher Id: 08-PONE-RA-03350R1
DOI: 10.1371/journal.pone.0002370

Moderate Alcohol Use and Mortality from Ischaemic Heart Disease: A Prospective Study in Older Chinese People Alternate Title:Alcohol and IHD Mortality
C. Mary Schooling1
Sun Wenjie1
Sai Yin Ho1
Wai Man Chan2
May Ked Tham2
Kin Sang Ho2
Gabriel M. Leung1*
Tai Hing Lam1
S. V. Subramanianedit1 Role: Editor
1Department of Community Medicine and School of Public Health, The University of Hong Kong, Hong Kong SAR, China
2Department of Health, The Government of the Hong Kong Special Administrative Region, Hong Kong SAR, China
Harvard School of Public Health, United States of America
Correspondence: * E-mail:
Contributed by footnote: Conceived and designed the experiments: GL CS TL WC MT KH. Analyzed the data: CS WS. Contributed reagents/materials/analysis tools: WC MT KH. Wrote the paper: CS. Other: Critically reviewed the paper for important intellectual content: WS KH SH WC MT TL GL.


Many observational studies have shown that moderate alcohol use is associated with lower mortality from ischemic heart disease (IHD) [1][4]. Despite these findings, there are counter examples [5][8]. Observational studies, prospective or case-control, cannot distinguish whether the protection offered by alcohol is casual or due to moderate alcohol use acting as a marker for other mortality related factors, such as healthier behaviours [9], [10], more social integration [11] or better health status [12]. Many of these studies have come from western countries, where moderate alcohol use and lower risk of ischaemic heart disease may both be associated with higher socio-economic status [13][16]. Moreover, alcohol use is often a normal part of social interaction. Thus it is difficult to assess whether the apparent beneficial effect of moderate alcohol use on ischaemic heart disease mortality is real or the result of uncontrollable (or uncontrolled) residual confounding [17].

Evidence from settings with different social patterns of alcohol use and ischaemic heart disease can potentially make a contribution. Compared with many western countries, alcohol use is less prevalent and more restrained in southern Chinese, so the characteristics of moderate users may be different. In Hong Kong, only 55% of men and 19% of women drink alcohol with an average daily intake amongst alcohol users of 9 grams ethanol in men and 2 grams in women, and the main alcoholic beverage is beer [18]. In contrast, use of alcohol is more common in northern China, Japan and South Korea [19][21]. Moreover in Hong Kong ischemic heart disease is not clearly associated with lower socio-economic status although alcohol use may be [18], [22]. There have been few prospective studies of alcohol use and IHD mortality in Chinese [23], [24]. Both previous studies in men from Shanghai suggested that moderate alcohol use was associated with lower IHD mortality. Although, in both studies, moderate alcohol use had rather systematic effects, which suggests that some favorable characteristics of the moderate alcohol users may also have been playing a role. We took advantage of a large prospective cohort of older men and women to re-examine the relation between moderate alcohol use and IHD mortality.


Details of the methods have been reported elsewhere [25]. Briefly, in July 1998, 18 Elderly Health Centers were established by the Department of Health, Government of HKSAR, to deliver health examinations and primary health care services for the elderly. All aged 65 years or older were eligible to enroll, and all those first enrolled from July 1998 to December 2000 were included in this study. More women enrolled than men; otherwise the subjects were similar in age, socio-economic status, current smoking and hospital use to the general elderly population [25].

Alcohol use

Alcohol use was initially recorded in four categories i.e. never-drinker, ex-drinker, social drinker and regular drinker. Social drinkers are people do not usually drink alcohol, but who may drink alcohol at social gatherings on special festive occasions, such as at Chinese New Year or a wedding. Regular drinkers were further asked if they drank more than 3 units per day (men) or 2 units per day (women). A unit was defined as 10 grams of ethanol, and the interviewer was provided with a list for converting common alcoholic drinks into units, for example a 335 ml can of beer at 5% is 1.4 units. On this basis regular drinkers were categorized as moderate or excessive. Moderate drinkers were defined as regular drinkers of 3 or fewer units per day in men and 2 or fewer units per day in women. Excessive drinkers were defined as regular drinkers of more than 3 units per day in men and 2 units per day in women. Self-reports of alcohol use are prone to mis-reporting; as a check, we examined the association between alcohol use and esophageal cancer.


Vital status was ascertained from death registration, special outpatient and hospitalization databases in Hong Kong by record linkage using the unique Hong Kong identity card number. The last date of follow-up or censor date was December 31, 2003. The subjects not found dead or alive by record linkage were followed up by telephone interview from November 2004 to January 2005, after which only 3.5% (1951) remained untraced. Adjusted for age, socio-economic status, lifestyle habits, untraced men were no different in alcohol use from traced men, but untraced women were significantly more likely to be social or excessive drinkers (odds ratio of being lost to follow-up 1.25 (95% CI 1.03 to 1.50) and 3.24 (95% CI 1.38 to 7.60) for social drinking and excessive drinking women respectively compared with never drinking women). Among the 54216 traced subjects, 3884 had died by December 31, 2003. Causes of death obtained for 3825 were routinely coded by the Department of Health according to the International Classification of Disease – 9th Revisions before 2001 and 10th Revision in and after 2001. Most Hong Kong residents die in hospital, enabling accurate ascertainment of cause of death, which we have used previously in similar studies [26].


The primary outcome was cause-specific mortality from the IHD (ICD-9 410-4 or ICD-10 I20-5); a secondary outcome was cause specific mortality from cancer of the esophagus (ICD-9 150 or ICD10 C15).

Statistical analysis

Chi-square tests were used to compare proportions of subject's characteristics across alcohol use groups. The Cox proportional hazards model was used to estimate the hazard ratios (HR) and the 95% confidence intervals (CI) for IHD and esophagus cancer mortality by alcohol use group adjusted in model 1 for age and in model 2 additionally for all other baseline potential confounders (education, monthly personal expenditure, housing type, exercise, body mass index (BMI) and smoking status), categorized as in Table 1. The proportional hazards assumption was checked by visual inspection of plots of log (- log (S)) against time, where S was the estimated survival function. Subjects who died of any other causes were regarded as censored at the date of death [27], [28]. Men and women were analyzed separately, because of the different patterns of alcohol use in men and women in Chinese society. Ethics approval was obtained from the Ethics Committee of the Faculty of Medicine, the University of Hong Kong. The study complied with the Declaration of Helsinki.


There were 18,750 men and 37,417 women in the study. After excluding 1951 clients with no follow-up information and 126 clients with missing, relevant baseline data, there were 95.5% (54,090) with follow-up and complete baseline data, including 3819 deaths. There were 188 and 218 deaths from IHD in men and women respectively and 24 and 10 from cancer of the esophagus in men and women. Men were much more likely to use alcohol than women (Table 1). Never-drinkers were much more likely to be never-smokers than current or former alcohol users in both sexes. Ex-drinkers were older in men and women. In men, never and social drinkers were better educated and more likely to live in self-owned accommodation.

In men there was no association between occasional or moderate alcohol use and death from IHD with hazard ratios of almost exactly unity (Table 2) in both models, although male excessive drinkers had a non-significantly lower risk of IHD mortality. However, male excessive drinkers also had an increased risk of cancer of the esophagus (HR 9.42: 95% CI 2.63 to 33.8). In women, because of the low numbers of moderate and excessive drinkers, all current drinkers were combined. In this group of mainly (89%) social drinkers, alcohol use was associated with slightly lower risk of IHD (adjusted HR 0.88, 95% CI 0.51 to 1.53) and had no effect on cancer of the esophagus.


In a large prospective study of older Chinese, we found no overall association between moderate alcohol use and lower mortality from IHD in either men or women, which is somewhat different from the two previous prospective studies of alcohol and IHD mortality in Chinese men. However, one of these studies from four small communities in Shanghai found moderate alcohol use associated both with a 36% reduction in IHD mortality and with a non-significant reduction in mortality from causes where alcohol usually has no effect or monotonically increases risk, [23] such as liver cancer, lung cancer, hepatic cirrhosis and injuries and accidents [29][33]. Such systematic effects suggest that some favorable characteristics of the moderate alcohol users may also have been playing a role, and which was not adequately controlled for. The other study did not specifically consider moderate alcohol use and IHD mortality [24], but instead found that moderate alcohol use protected against all cardiovascular mortality, despite the relatively high proportion of hemorrhagic strokes in China [34], for which alcohol would not be expected to be protective [35].

There are several possible explanations for the differences between our study and a large body of evidence showing that moderate alcohol use protects against IHD mortality. First, the period of follow up was relatively short, with correspondingly few deaths, but also less error due to change in alcohol use. Second, the participants were volunteer attendees at a primary care facility, who might be generally healthier with less need of the potential protection offered by alcohol. Third, we distinguished between life-long never-drinkers, ex-drinkers, occasional (or social drinkers) and moderate drinkers, so that the reference group of never-drinkers was not contaminated by “sick quitters” or people who had never used alcohol because of ill-health. Fourth, the association of alcohol use with IHD may vary with age, however most previous studies have found benefits in older people [36]. Fifth, our participants may have been drinking too much or too little alcohol. Given, the generally low level of alcohol use in Hong Kong [18] and the non-significantly protective effect of excessive use, it is most unlikely that our subjects drank too much alcohol. However, we cannot rule out the possibility that they were drinking too little, particularly the women, who were almost entirely social drinkers. Alternatively the alcohol could have been consumed in binge drinking sessions, however that is unusual in Chinese [18] and in older persons [37]. Sixth, our participants may have been using the wrong type of alcohol, as western or grape wine is rarely drunk [18]. However, ethanol is largely responsible for the cardio-protective effects, although there may be some additional protection from some constituents of red wine [38]. Seventh, our findings may be the result of uncontrolled residual confounding, although our findings were the same with adjustment only for age, or with additional adjustment for socio-economic status and lifestyle, which suggests that confounding due to these adjusted factors is not playing a major role.

Nevertheless, despite these limitations it is possible that moderate alcohol use may have less effect on IHD mortality in some settings, perhaps because of role of co-factor, such as folate intake, [39] or because of the relative importance of the different cardio-protective and detrimental aspects of alcohol. Alcohol raises blood pressure [40], [41], but it also raises HDL-cholesterol [42] and possibly improves insulin sensitivity [42]. Depending on the relative importance of these factors to IHD mortality in different settings, it is possible that the effects of alcohol use may differ, with alcohol being most protective in settings where low HDL is the key factor in IHD, and less protective in settings where high blood pressure is the key factor in IHD. There is some preliminary evidence suggesting that HDL-cholesterol may be a less important predictive factor for IHD events in Chinese than in the Framingham cohort, whilst systolic blood pressure may be more important for cardiovascular events in Asians than the Framingham cohort [43], [44]. We do not have HDL-cholesterol for this cohort, so we cannot investigate whether the effects of alcohol varied with HDL-cholesterol and blood pressure.


In a population-based prospective study of older Chinese people with or without adjustment for multiple confounders, there was no association between moderate alcohol use and lower IHD mortality. This could be a chance association, or it could indicate that moderate alcohol use may not be as protective against IHD some sub-populations, for reasons which need to be clarified.


Competing Interests: The authors have declared that no competing interests exist.

Funding: This project was funded by the Health Care & Promotion Fund Committee in Hong Kong (Grant: HSRC#S111016). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

We wish to thank the staff of the Elderly Health Centres and the Hospital Authority for their assistance in data collection and entry.

1. Marmot MG. 1984;Alcohol and coronary heart disease.Int J Epidemiol 13:160–167. [pmid: 6376385]
2. Corrao G,Rubbiati L,Bagnardi V,Zambon A,Poikolainen K. 2000;Alcohol and coronary heart disease: a meta-analysis.Addiction 95:1505–1523. [pmid: 11070527]
3. Gronbaek M. 2002;Alcohol, type of alcohol, and all-cause and coronary heart disease mortality.Ann N Y Acad Sci 957:16–20.:16–20. [pmid: 12074958]
4. Doll R,Peto R,Boreham J,Sutherland I. 2005;Mortality in relation to alcohol consumption: a prospective study among male British doctors.Int J Epidemiol 34:199–204. [pmid: 15647313]
5. Hart CL,Smith GD,Hole DJ,Hawthorne VM. 1999;Alcohol consumption and mortality from all causes, coronary heart disease, and stroke: results from a prospective cohort study of scottish men with 21 years of follow up.BMJ 318:1725–1729. [pmid: 10381706]
6. Shaper AG,Wannamethee SG. 2000;Alcohol intake and mortality in middle aged men with diagnosed coronary heart disease.Heart 83:394–399. [pmid: 10722536]
7. Strandberg AY,Strandberg TE,Salomaa VV,Pitkala K,Miettinen TA. 2004;Alcohol consumption, 29-y total mortality, and quality of life in men in old age.Am J Clin Nutr 80:1366–1371. [pmid: 15531688]
8. Deev A,Shestov D,Abernathy J,Kapustina A,Muhina N,et al. 1998;Association of alcohol consumption to morality in middle-aged U.S. and Russian men and women.Ann Epidemiol 8:147–153. [pmid: 9548999]
9. Fillmore KM,Golding JM,Graves KL,Kniep S,Leino EV,et al. 1998;Alcohol consumption and mortality. I. Characteristics of drinking groups.Addiction 93:183–203. [pmid: 9624721]
10. Naimi TS,Brown DW,Brewer RD,Giles WH,Mensah G,et al. 2005;Cardiovascular risk factors and confounders among nondrinking and moderate-drinking U.S. adults.Am J Prev Med 28:369–373. [pmid: 15831343]
11. Fuchs FD,Chambless LE,Folsom AR,Eigenbrodt ML,Duncan BB,et al. 2004;Association between alcoholic beverage consumption and incidence of coronary heart disease in whites and blacks: the Atherosclerosis Risk in Communities Study.Am J Epidemiol 160:466–474. [pmid: 15321844]
12. Fillmore KM,Kerr WC,Stockwell T,Chikritzhs T,Bostrom A. 2006;Moderate alcohol use and reduced mortality risk: systematic error in prospective studies.Addiction Research and Theory 14:101–132.
13. Bartley M,Sacker A,Firth D,Fitzpatrick R. 1999;Understanding social variation in cardiovascular risk factors in women and men: the advantage of theoretically based measures.Soc Sci Med 49:831–845. [pmid: 10459894]
14. Wray LA,Alwin DF,McCammon RJ. 2005;Social status and risky health behaviors: results from the health and retirement study.J Gerontol B Psychol Sci Soc Sci 60 Spec No 2:85–92.:85–92. [pmid: 16251597]
15. Mortensen EL,Jensen HH,Sanders SA,Reinisch JM. 2006;Associations between volume of alcohol consumption and social status, intelligence, and personality in a sample of young adult Danes.Scand J Psychol 47:387–398. [pmid: 16987208]
16. Kunst AE,Groenhof F,Andersen O,Borgan JK,Costa G,et al. 1999;Occupational class and ischemic heart disease mortality in the United States and 11 European countries.Am J Public Health 89:47–53. [pmid: 9987464]
17. Jackson R,Broad J,Connor J,Wells S. 2005;Alcohol and ischaemic heart disease: probably no free lunch.Lancet 366:1911–1912. [pmid: 16325685]
18. Janghorbani M,Ho SY,Lam TH,Janus ED. 2003;Prevalence and correlates of alcohol use: a population-based study in Hong Kong.Addiction 98:215–224. [pmid: 12534427]
19. Cochrane J,Chen H,Conigrave KM,Hao W. 2003;Alcohol use in China.Alcohol Alcohol 38:537–542. [pmid: 14633640]
20. Higuchi S,Matsushita S,Maesato H,Osaki Y. 2007;Japan: alcohol today.Addiction 102:1849–1862. [pmid: 17680852]
21. Yoon YS,Oh SW,Baik HW,Park HS,Kim WY. 2004;Alcohol consumption and the metabolic syndrome in Korean adults: the 1998 Korean National Health and Nutrition Examination Survey.Am J Clin Nutr 80:217–224. [pmid: 15213051]
22. Wong SL,Donnan SP. 1992;Influence of socioeconomic status on cardiovascular diseases in Hong Kong.J Epidemiol Community Health 46:148–150. [pmid: 1583430]
23. Yuan JM,Ross RK,Gao YT,Henderson BE,Yu MC. 1997;Follow up study of moderate alcohol intake and mortality among middle aged men in Shanghai, China.BMJ 314:18–23. [pmid: 9001474]
24. Xu WH,Zhang XL,Gao YT,Xiang YB,Gao LF,et al. 2007;Joint effect of cigarette smoking and alcohol consumption on mortality.Prev Med 45:313–319. [pmid: 17628652]
25. Schooling CM,Lam TH,Li ZB,Ho SY,Chan WM,et al. 2006;Obesity, physical activity, and mortality in a prospective chinese elderly cohort.Arch Intern Med 166:1498–1504. [pmid: 16864760]
26. Lam TH,Ho SY,Hedley AJ,Mak KH,Peto R. 2001;Mortality and smoking in Hong Kong: case-control study of all adult deaths in 1998.BMJ 323:361. [pmid: 11509422]
27. Satagopan JM,Ben Porat L,Berwick M,Robson M,Kutler D,et al. 2004;A note on competing risks in survival data analysis.Br J Cancer 91:1229–1235. [pmid: 15305188]
28. Andersen PK,Abildstrom SZ,Rosthoj S. 2002;Competing risks as a multi-state model.Stat Methods Med Res 11:203–215. [pmid: 12040697]
29. Bagnardi V,Blangiardo M,La Vecchia C,Corrao G. 2001;Alcohol consumption and the risk of cancer: a meta-analysis.Alcohol Res Health 25:263–270. [pmid: 11910703]
30. Bandera EV,Freudenheim JL,Vena JE. 2001;Alcohol consumption and lung cancer: a review of the epidemiologic evidence.Cancer Epidemiol Biomarkers Prev 10:813–821. [pmid: 11489747]
31. Boffetta P,Hashibe M. 2006;Alcohol and cancer.Lancet Oncol 7:149–156. [pmid: 16455479]
32. Corrao G,Bagnardi V,Zambon A,Arico S. 1999;Exploring the dose-response relationship between alcohol consumption and the risk of several alcohol-related conditions: a meta-analysis.Addiction 94:1551–1573. [pmid: 10790907]
33. Korte JE,Brennan P,Henley SJ,Boffetta P. 2002;Dose-specific meta-analysis and sensitivity analysis of the relation between alcohol consumption and lung cancer risk.Am J Epidemiol 155:496–506. [pmid: 11882523]
34. Liu M,Wu B,Wang WZ,Lee LM,Zhang SH,et al. 2007;Stroke in China: epidemiology, prevention, and management strategies.Lancet Neurol 6:456–464. [pmid: 17434100]
35. Reynolds K,Lewis B,Nolen JD,Kinney GL,Sathya B,et al. 2003;Alcohol consumption and risk of stroke: a meta-analysis.JAMA 289:579–588. [pmid: 12578491]
36. Mukamal KJ,Chung H,Jenny NS,Kuller LH,Longstreth WT Jr.,et al. 2006;Alcohol consumption and risk of coronary heart disease in older adults: the Cardiovascular Health Study.J Am Geriatr Soc 54:30–37. [pmid: 16420195]
37. Serdula MK,Brewer RD,Gillespie C,Denny CH,Mokdad A. 2004;Trends in alcohol use and binge drinking, 1985-1999: results of a multi-state survey.Am J Prev Med 26:294–298. [pmid: 15110055]
38. Gronbaek M. 2003;Alcohol and cardiovascular disease–more than one paradox to consider. Type of alcoholic beverage and cardiovascular disease–does it matter?J Cardiovasc Risk 10:5–10. [pmid: 12569230]
39. Jiang R,Hu FB,Giovannucci EL,Rimm EB,Stampfer MJ,et al. 2003;Joint association of alcohol and folate intake with risk of major chronic disease in women.Am J Epidemiol 158:760–771. [pmid: 14561666]
40. Dickinson HO,Mason JM,Nicolson DJ,Campbell F,Beyer FR,et al. 2006;Lifestyle interventions to reduce raised blood pressure: a systematic review of randomized controlled trials.J Hypertens 24:215–233. [pmid: 16508562]
41. McFadden CB,Brensinger CM,Berlin JA,Townsend RR. 2005;Systematic review of the effect of daily alcohol intake on blood pressure.Am J Hypertens 18:276–286. [pmid: 15752957]
42. Rimm EB,Williams P,Fosher K,Criqui M,Stampfer MJ. 1999;Moderate alcohol intake and lower risk of coronary heart disease: meta-analysis of effects on lipids and haemostatic factors.BMJ 319:1523–1528. [pmid: 10591709]
43. Liu J,Hong Y,D'Agostino RB Sr.,Wu Z,Wang W,et al. 2004;Predictive value for the Chinese population of the Framingham CHD risk assessment tool compared with the Chinese Multi-Provincial Cohort Study.JAMA 291:2591–2599. [pmid: 15173150]
44. Barzi F,Patel A,Gu D,Sritara P,Lam TH,et al. 2007;Cardiovascular risk prediction tools for populations in Asia.J Epidemiol Community Health 61:115–121. [pmid: 17234869]

[TableWrap ID: pone-0002370-t001] doi: 10.1371/journal.pone.0002370.t001.
Table 1  Baseline characteristics of 54090 enrollees at Elderly Health Centres in Hong Kong from 1998 to 2000 with follow-up
Men Women
Alcohol use status Alcohol use status
Never drinker (n = 9,177) Ex-drinker (n = 3,300) Social (n = 3,957) Moderate (n = 1,318) Excessive (n = 375) χ2 p-value Never drinker (n = 30,763) Ex-drinker (n = 1,987) Social (n = 2,856) Moderate (n = 306) Excessive (n = 51) χ2 p-value
Age group 65-9 38.2 30.6 46.0 42.3 44.3 39.5 32.2 46.7 39.2 47.1
70-4 31.4 34.0 32.1 34.2 36.0 30.3 32.4 29.2 32.7 29.4
75-9 19.4 21.2 15.1 16.2 13.1 18.5 20.8 16.2 19.3 15.7
80-4 8.0 10.5 5.5 5.7 4.8 8.2 9.7 6.0 6.5 3.9
≥85 3.0 3.7 1.3 1.6 1.9 <0.001 3.6 5.0 1.9 2.3 3.9 <0.001
Education Post-secondary 8.0 4.2 6.5 5.6 4.0 1.9 1.4 2.0 1.6 0.0
Secondary 25.7 18.0 24.7 21.1 17.3 8.1 4.3 8.0 9.2 7.8
Primary 49.9 55.0 53.1 53.7 54.1 29.4 25.5 30.2 27.1 29.4
No formal education but literate 9.5 13.0 9.2 10.9 14.9 19.8 23.6 21.7 18.6 23.5
Illiterate 6.9 9.9 6.6 8.7 9.6 <0.001 41.0 45.2 38.1 43.5 39.2 <0.001
Housing Public or aided 37.9 43.8 40.0 42.6 45.1 39.9 41.1 42.2 43.1 37.3
Private housing (rent) 6.1 5.8 4.6 4.3 5.3 4.7 5.0 5.0 7.2 2.0
Private housing (self-owned flat) 49.8 42.8 51.4 47.9 43.7 47.4 44.1 48.4 43.8 58.8
Temporary housing 0.8 1.1 0.6 1.5 1.9 1.0 1.5 0.8 2.0 0.0
Institutions 3.4 4.8 1.5 2.0 2.1 4.9 7.4 2.1 1.6 2.0
Others 2.1 1.7 1.9 1.7 1.9 <0.001 2.1 1.0 1.6 2.3 0.0 <0.001
Exercise Never 16.5 15.9 16.6 18.1 31.2 14.2 14.2 16.0 17.0 17.7
<30 minutes per day 32.4 34.0 36.0 35.2 31.2 35.8 38.7 37.7 36.0 23.5
≥30 minutes per day 51.1 50.1 47.5 46.7 37.6 <0.001 50.0 47.1 46.3 47.1 58.8 0.001
Monthly expenditure <1000HK$ 12.1 12.9 12.2 9.4 9.1 17.2 17.5 14.9 17.7 15.7
1000- <2000 HK$ 36.1 37.2 37.0 37.9 28.5 39.4 38.5 40.2 38.6 29.4
2000- <3000 HK$ 30.9 32.0 31.6 32.8 36.5 29.5 28.4 29.1 29.4 21.6
3000- <6000 HK$ 17.8 15.6 16.1 16.8 22.1 12.4 14.5 14.2 13.1 31.4
6000- <10000 HK$ 2.3 1.6 2.3 2.4 2.9 1.1 0.8 1.4 1.0 2.0
≥10000 HK$ 1.0 0.6 0.9 0.6 0.8 <0.001 0.4 0.3 0.3 0.3 0.0 0.002
Smoking status Never-smoker 53.2 16.5 31.0 27.1 12.5 90.8 64.7 78.0 66.0 58.8
Current smoker 16.5 19.0 22.0 31.7 54.4 3.3 5.5 8.5 17.7 23.5
Ex-smoker 30.3 64.5 47.0 41.2 33.1 <0.001 5.9 29.7 13.5 16.3 17.7 <0.001
Body mass index <18.5 6.3 7.0 4.1 5.3 5.1 5.3 5.4 4.7 8.2 9.8
18.5-<23 33.7 32.2 32.7 34.8 45.6 30.9 29.9 30.0 33.0 23.5
23-<25 24.0 24.1 23.6 23.6 24.0 21.8 21.3 22.1 17.3 23.5
25-<30 32.4 32.3 35.4 33.2 20.5 34.7 35.3 34.7 36.0 39.2
≥30 3.6 4.4 4.3 3.1 4.8 <0.001 7.3 8.0 8.6 5.6 3.9 0.10

[TableWrap ID: pone-0002370-t002] doi: 10.1371/journal.pone.0002370.t002.
Table 2  Hazard ratios with 95% confidence intervals for mortality from IHD and cancer of the esophagus by level of alcohol use in men and women
Model 1 Model 2
Cause of death Alcohol use Number of deaths Years of follow-up HR 95% CI HR 95% CI
Men IHD Never drinker 92 37,268 1 1
Ex- drinker 48 13,228 1.36 0.96 to 1.93 1.33 0.91 to 1.93
Social Drinker 34 15,899 0.99 0.67 to 1.47 1.02 0.68 to 1.53
Moderate 12 5,291 1.01 0.55 to 1.84 1.00 0.54 to 1.83
Excessive 2 1,502 0.62 0.15 to 2.52 0.56 0.14 to 2.29
Esophagus cancer Never drinker 9 1 1
Ex- drinker 5 1.59 0.53 to 4.77 1.24 0.39 to 3.92
Social Drinker 2 0.54 0.12 to 2.51 0.52 0.11 to 2.46
Moderate 4 3.22 0.99 to 10.48 2.91 0.87 to 9.76
Excessive 4 11.27 3.45 to 36.74 9.42 2.63 to 33.8
Women IHD Never drinker 185 129,470 1 1
Ex- drinker 19 8,271 1.40 0.87 to 2.25 1.30 0.80 to 2.13
Current drinker* 14 12,970 0.90 0.52 to 1.55 0.88 0.51 to 1.53
Esophagus cancer Never drinker 8 1 1
Ex- drinker 1 1.81 0.23 to 14.6 1.07 0.12 to 9.46
Current drinker* 1 1.34 0.17 to 10.8 1.03 0.12 to 8.71

nt101Model 1 Adjusted for age group.

nt102Model 2 Adjusted for age group, smoking status, education, housing, monthly expenditure, body mass index group and exercise.

*All three current alcohol use groups were combined for women because of the small number of moderate and excessive drinkers in women.

Article Categories:
  • Research Article
Article Categories:
  • Cardiovascular Disorders/Coronary Artery Disease
  • Public Health and Epidemiology/Social and Behavioral Determinants of Health

Previous Document:  A randomized, placebo-controlled trial of the bivalent killed, whole-cell, oral cholera vaccine in a...
Next Document:  Genesis of neuronal and glial progenitors in the cerebellar cortex of peripuberal and adult rabbits.