Document Detail

Moderate alcohol consumption, dietary fat composition, and abdominal obesity in women: evidence for gene-environment interaction.
MedLine Citation:
PMID:  14602777     Owner:  NLM     Status:  MEDLINE    
We examined relationships among alcohol intake, dietary fat composition, and total body fat (TBF) and central abdominal fat (CAF), independent of genetic confounders, and evaluated the modulating effect of genetic susceptibility. We studied 334 female twins (57.7 +/- 6.7 yr) after excluding dietary underreporters. Diet was assessed by Food-Frequency Questionnaire and body fat by dual-energy x-ray absorptiometry. Moderate alcohol consumers (12-17.9 g/d) had less TBF (20.6 +/- 5.6 vs. 24.8 +/- 8.4 kg, P = 0.03) and CAF (1.2 +/- 0.6 vs. 1.6 +/- 0.7 kg, P = 0.03) than abstainers. In multiple regression, alcohol consumption remained independently associated with body fat distribution. In cotwin case-control (monozygotic twin) analysis, moderate alcohol consumption accounted for 300 g less CAF, independent of genetic and other environmental factors. Gene-environment interaction analysis indicated that this association was limited to subjects at high genetic risk of abdominal obesity. There was no relationship between dietary fat composition and adiposity. However, in women at low genetic risk of abdominal obesity, subjects with polyunsaturated fat intakes in the highest tertile had about 50% less CAF than subjects with intakes in the lowest tertile (0.9 +/- 0.4 vs. 1.6 +/- 0.4 kg, P = 0.0007), an association absent in subjects with high genetic risk. In conclusion, genetic risk modulates relationships between dietary factors and adiposity. Lower abdominal fat may mediate associations between dietary intake and type 2 diabetes risk.
Jerry R Greenfield; Katherine Samaras; Arthur B Jenkins; Paul J Kelly; Tim D Spector; Lesley V Campbell
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Twin Study    
Journal Detail:
Title:  The Journal of clinical endocrinology and metabolism     Volume:  88     ISSN:  0021-972X     ISO Abbreviation:  J. Clin. Endocrinol. Metab.     Publication Date:  2003 Nov 
Date Detail:
Created Date:  2003-11-06     Completed Date:  2003-12-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375362     Medline TA:  J Clin Endocrinol Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  5381-6     Citation Subset:  AIM; IM    
Department of Endocrinology, St. Vincent's Hospital, Darlinghurst, 2010 Sydney, Australia.
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MeSH Terms
Alcohol Drinking*
Case-Control Studies
Cross-Sectional Studies
Dietary Fats / administration & dosage*
Genetic Predisposition to Disease / epidemiology
Middle Aged
Obesity / epidemiology,  genetics*
Risk Factors
Twins, Monozygotic
Reg. No./Substance:
0/Dietary Fats

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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