Document Detail


Moderate acute intake of de-alcoholized red wine, but not alcohol, is protective against radiation-induced DNA damage ex vivo -- results of a comparative in vivo intervention study in younger men.
MedLine Citation:
PMID:  16083915     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Moderate intake of wine is associated with reduced risk of cardiovascular disease and possibly cancer however it remains unclear whether the potential health benefits of wine intake are due to alcohol or the non-alcoholic fraction of wine. We therefore tested the hypothesis that the non-alcoholic fraction of wine protects against genome damage induced by oxidative stress in a crossover intervention study involving six young adult males aged 21-26 years. The participants adhered to a low plant phenolic compound diet for 48 h prior to consuming 300 mL of complete red wine, de-alcoholized red wine or ethanol on separate occasions 1 week apart. Blood samples were collected 0.5, 1.0 and 2.0 h after beverage consumption. Baseline and radiation-induced genome damage was measured using the cytokinesis-block micronucleus assay and total plasma catechin concentration was measured. Consumption of de-alcoholized red wine significantly decreased the gamma radiation-induced DNA damage at 1 and 2 h post-consumption by 20%. In contrast alcohol tended to increase radiation-induced genome damage and complete wine protected against radiation-induced genome damage relative to alcohol. The observed effects were only weakly correlated with the concentration of total plasma catechin (R=-0.23). These preliminary data suggest that only the non-alcoholic fraction of red wine protects DNA from oxidative damage but this effect cannot be explained solely by plasma catechin.
Authors:
W Greenrod; C S Stockley; P Burcham; M Abbey; M Fenech
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-08-03
Journal Detail:
Title:  Mutation research     Volume:  591     ISSN:  0027-5107     ISO Abbreviation:  Mutat. Res.     Publication Date:  2005 Dec 
Date Detail:
Created Date:  2005-11-23     Completed Date:  2006-09-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0400763     Medline TA:  Mutat Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  290-301     Citation Subset:  IM    
Affiliation:
CSIRO Health Sciences and Nutrition, Genome Health and Nutrigenomics Laboratory, PO Box 10041, Adelaide BC, SA 5000, Australia.
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MeSH Terms
Descriptor/Qualifier:
Adult
Alcohol Drinking*
Catechin / blood
DNA / radiation effects*
DNA Damage*
Ethanol / administration & dosage*,  metabolism
Humans
Intervention Studies
Lymphocytes / physiology,  radiation effects
Male
Micronucleus Tests
Phenols / chemistry,  metabolism
Wine*
Chemical
Reg. No./Substance:
0/Phenols; 154-23-4/Catechin; 64-17-5/Ethanol; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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