Document Detail

Moderate unconjugated hyperbilirubinemia causes a transient but delayed suppression of amplitude-integrated electroencephalographic activity in preterm infants.
MedLine Citation:
PMID:  22699267     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Unconjugated hyperbilirubinemia occurs frequently in preterm infants and may result in bilirubin encephalopathy. Amplitude-integrated electroencephalography (aEEG) is used to evaluate brain function in newborns.
OBJECTIVES: To investigate the influence of total serum bilirubin (TSB) on the aEEG amplitude of preterm infants and to evaluate aEEG as a noninvasive method to identify acute bilirubin encephalopathy.
METHODS: We performed a prospective observational study of 34 infants with a gestational age (GA) of 26-31 6/7 weeks. Infants had aEEG recordings on the 1st-5th, 8th and 15th day after birth. Infants with asphyxia, intraventricular hemorrhage >grade I or circulatory insufficiency were excluded. aEEG was evaluated by calculating the mean 5th, 50th and 95th centiles of the aEEG amplitudes.
RESULTS: TSB peaked on the 4th day after birth. There was no synchronous relationship between TSB and aEEG amplitudes. The 5th, 50th, and 95th aEEG amplitude centiles on the 8th day correlated negatively with the TSB peak value (r = -0.37, p = 0.048; r = -0.60, p = 0.001; r = -0.44, p = 0.017, respectively), irrespective of GA. The 5th and 50th aEEG amplitude centiles increased with increasing GA (r = 0.45, p < 0.001, and r = 0.26, p < 0.001, respectively) and postnatal age (r = 0.25, p < 0.001, and r = 0.16, p = 0.023, respectively).
CONCLUSIONS: TSB had no direct effect on aEEG amplitudes in preterm infants. There is, however, a delayed effect on electrocerebral activity in the 2nd week after birth.
Hendrik J Ter Horst; Arend F Bos; Jildou Duijvendijk; Christian V Hulzebos
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Publication Detail:
Type:  Journal Article     Date:  2012-06-14
Journal Detail:
Title:  Neonatology     Volume:  102     ISSN:  1661-7819     ISO Abbreviation:  Neonatology     Publication Date:  2012  
Date Detail:
Created Date:  2012-08-14     Completed Date:  2012-12-27     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  101286577     Medline TA:  Neonatology     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  120-5     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 S. Karger AG, Basel.
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MeSH Terms
Analgesics, Opioid / administration & dosage
Bilirubin / blood
Biological Markers / blood
Brain / drug effects,  physiopathology*
Brain Waves* / drug effects
Gestational Age
Hyperbilirubinemia, Neonatal / blood,  complications*,  diagnosis,  physiopathology,  therapy
Infant, Newborn
Infant, Premature*
Kernicterus / blood,  diagnosis*,  etiology,  physiopathology
Linear Models
Morphine / administration & dosage
Multivariate Analysis
Predictive Value of Tests
Prospective Studies
Reg. No./Substance:
0/Analgesics, Opioid; 0/Biological Markers; 76I7G6D29C/Morphine; RFM9X3LJ49/Bilirubin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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