Document Detail

Moderate intensity, but not high intensity, treadmill exercise training alters power output properties in myocardium from aged rats.
MedLine Citation:
PMID:  22843668     Owner:  NLM     Status:  MEDLINE    
Aging is characterized by a progressive decline in cardiac function, but endurance exercise training has been shown to retard a number of deleterious effects of aging. However, underlying mechanisms by which exercise training improves age-related decrements in myocardial contractile function are not well understood. The purpose of this study was to determine the effects of exercise training on power output properties in permeablized (skinned) myocytes of old rats. Thirty-month-old rats were divided into sedentary control (C) and groups undergoing 11 weeks of treadmill exercise training at moderate intensity (MI) and at high intensity (HI). Peak power output normalized to maximal force was significantly increased in MI but not in HI compared to C with significant increases in atrial myosin light chain 1 in ventricle. These results suggest that MI exercise training is beneficial as a significant increase was seen in the ability of the myocardium to do work, but this effect was not seen with HI training.
Eunhee Chung; Gary M Diffee
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural     Date:  2012-07-25
Journal Detail:
Title:  The journals of gerontology. Series A, Biological sciences and medical sciences     Volume:  67     ISSN:  1758-535X     ISO Abbreviation:  J. Gerontol. A Biol. Sci. Med. Sci.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-10-15     Completed Date:  2013-01-10     Revised Date:  2013-11-06    
Medline Journal Info:
Nlm Unique ID:  9502837     Medline TA:  J Gerontol A Biol Sci Med Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1178-87     Citation Subset:  AIM; IM    
Balke Biodynamics Laboratory, Department of Kinesiology,University of Wisconsin-Madison, Madison, Wisconsin 53706-1121, USA.
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MeSH Terms
Aging / physiology*
Analysis of Variance
Cells, Cultured
Electrophoresis, Gel, Two-Dimensional
Exercise Test
Exercise Tolerance / physiology*
Models, Animal
Muscle Cells / cytology,  metabolism
Myocardial Contraction / physiology*
Myosin Light Chains / metabolism*
Physical Conditioning, Animal*
Random Allocation
Rats, Inbred F344
Rats, Sprague-Dawley
Grant Support
Reg. No./Substance:
0/Myosin Light Chains

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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